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Risk of dementia in APOE ε4 carriers is mitigated by a polygenic risk score

INTRODUCTION: We investigated relationships among genetic determinants of Alzheimer's disease (AD), amyloid/tau/neurodegenaration (ATN) biomarkers, and risk of dementia. METHODS: We studied cognitively normal individuals with subjective cognitive decline (SCD) from the Amsterdam Dementia Cohort...

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Detalles Bibliográficos
Autores principales:	Ebenau, Jarith L., van der Lee, Sven J., Hulsman, Marc, Tesi, Niccolò, Jansen, Iris E., Verberk, Inge M.W., van Leeuwenstijn, Mardou, Teunissen, Charlotte E., Barkhof, Frederik, Prins, Niels D., Scheltens, Philip, Holstege, Henne, van Berckel, Bart N.M., van der Flier, Wiesje M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438688/ https://www.ncbi.nlm.nih.gov/pubmed/34541285 http://dx.doi.org/10.1002/dad2.12229

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