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Bispecific binder redirected lentiviral vector enables in vivo engineering of CAR-T cells

BACKGROUND: Chimeric antigen receptor (CAR) T cells have shown considerable promise as a personalized cellular immunotherapy against B cell malignancies. However, the complex and lengthy manufacturing processes involved in generating CAR T cell products ex vivo result in substantial production time...

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Detalles Bibliográficos
Autores principales:	Huckaby, Justin T, Landoni, Elisa, Jacobs, Timothy M, Savoldo, Barbara, Dotti, Gianpietro, Lai, Samuel K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438880/ https://www.ncbi.nlm.nih.gov/pubmed/34518288 http://dx.doi.org/10.1136/jitc-2021-002737

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