Haemophagocytic lymphohistiocytosis in an adult with postacute COVID-19 syndrome

Haemophagocytic lymphohistiocytosis (HLH) causing multiorgan failure has been reported as an acute clinical presentation of COVID-19. However, the literature surrounding HLH in the context of a postacute COVID-19 syndrome is limited. This report presents a case of a life-threatening HLH occurring 6 ...

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Autores principales: Wiseman, Daniel, Lin, John, Routy, Jean-Pierre, Samoukovic, Gordan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438920/
https://www.ncbi.nlm.nih.gov/pubmed/34518190
http://dx.doi.org/10.1136/bcr-2021-245031
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author Wiseman, Daniel
Lin, John
Routy, Jean-Pierre
Samoukovic, Gordan
author_facet Wiseman, Daniel
Lin, John
Routy, Jean-Pierre
Samoukovic, Gordan
author_sort Wiseman, Daniel
collection PubMed
description Haemophagocytic lymphohistiocytosis (HLH) causing multiorgan failure has been reported as an acute clinical presentation of COVID-19. However, the literature surrounding HLH in the context of a postacute COVID-19 syndrome is limited. This report presents a case of a life-threatening HLH occurring 6 weeks after a pauci-symptomatic COVID-19 infection in a previously healthy adult. A bone marrow aspirate confirmed the HLH and the patient was successfully treated with dexamethasone and etoposide. To our knowledge, this is the first case of HLH occurring as a postacute COVID-19 syndrome following a pauci-symptomatic initial infection.
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spelling pubmed-84389202021-09-24 Haemophagocytic lymphohistiocytosis in an adult with postacute COVID-19 syndrome Wiseman, Daniel Lin, John Routy, Jean-Pierre Samoukovic, Gordan BMJ Case Rep Case Report Haemophagocytic lymphohistiocytosis (HLH) causing multiorgan failure has been reported as an acute clinical presentation of COVID-19. However, the literature surrounding HLH in the context of a postacute COVID-19 syndrome is limited. This report presents a case of a life-threatening HLH occurring 6 weeks after a pauci-symptomatic COVID-19 infection in a previously healthy adult. A bone marrow aspirate confirmed the HLH and the patient was successfully treated with dexamethasone and etoposide. To our knowledge, this is the first case of HLH occurring as a postacute COVID-19 syndrome following a pauci-symptomatic initial infection. BMJ Publishing Group 2021-09-13 /pmc/articles/PMC8438920/ /pubmed/34518190 http://dx.doi.org/10.1136/bcr-2021-245031 Text en © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. https://bmj.com/coronavirus/usageThis article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.
spellingShingle Case Report
Wiseman, Daniel
Lin, John
Routy, Jean-Pierre
Samoukovic, Gordan
Haemophagocytic lymphohistiocytosis in an adult with postacute COVID-19 syndrome
title Haemophagocytic lymphohistiocytosis in an adult with postacute COVID-19 syndrome
title_full Haemophagocytic lymphohistiocytosis in an adult with postacute COVID-19 syndrome
title_fullStr Haemophagocytic lymphohistiocytosis in an adult with postacute COVID-19 syndrome
title_full_unstemmed Haemophagocytic lymphohistiocytosis in an adult with postacute COVID-19 syndrome
title_short Haemophagocytic lymphohistiocytosis in an adult with postacute COVID-19 syndrome
title_sort haemophagocytic lymphohistiocytosis in an adult with postacute covid-19 syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438920/
https://www.ncbi.nlm.nih.gov/pubmed/34518190
http://dx.doi.org/10.1136/bcr-2021-245031
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AT linjohn haemophagocyticlymphohistiocytosisinanadultwithpostacutecovid19syndrome
AT routyjeanpierre haemophagocyticlymphohistiocytosisinanadultwithpostacutecovid19syndrome
AT samoukovicgordan haemophagocyticlymphohistiocytosisinanadultwithpostacutecovid19syndrome

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