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Triazole susceptibility of Aspergillus species: environmental survey in Lagos, Nigeria and review of the rest of Africa

BACKGROUND: Triazole resistance is an emerging problem in the management of human aspergillosis globally and can arise in Aspergillus species which have been exposed to azole fungicides in the environment. We surveyed local government and council development areas in Lagos, Nigeria, to determine the...

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Autores principales: Campbell, Cynthia Abosede, Osaigbovo, Iriagbonse Iyabo, Oladele, Rita Okeoghene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438939/
https://www.ncbi.nlm.nih.gov/pubmed/34532039
http://dx.doi.org/10.1177/20499361211044330
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author Campbell, Cynthia Abosede
Osaigbovo, Iriagbonse Iyabo
Oladele, Rita Okeoghene
author_facet Campbell, Cynthia Abosede
Osaigbovo, Iriagbonse Iyabo
Oladele, Rita Okeoghene
author_sort Campbell, Cynthia Abosede
collection PubMed
description BACKGROUND: Triazole resistance is an emerging problem in the management of human aspergillosis globally and can arise in Aspergillus species which have been exposed to azole fungicides in the environment. We surveyed local government and council development areas in Lagos, Nigeria, to determine the distribution of Aspergillus species in the environment and their susceptibility to locally available triazole antifungal agents. We also reviewed the literature on the subject from the rest of Africa. METHODS: A total of 168 soil samples from six locations in Lagos, Nigeria were processed and cultured on Saboraud dextrose agar impregnated with chloramphenicol to isolate Aspergillus species. Isolates were tested for susceptibility to itraconazole and voriconazole by microbroth dilution according to the European Committee on Antimicrobial Susceptibility Testing reference method. Relevant databases were searched to identify published work pertaining to triazole susceptibility of Aspergillus species in Africa. RESULTS: A total of 117 Aspergillus species were isolated. Aspergillus niger was the most frequently isolated species (42.7%). Other species isolated were Aspergillus flavus, 37 (31.6%), Aspergillus terreus, 20 (17.1%), Aspergillus fumigatus, 5 (4.3%) and Aspergillus nidulans, 5 (4.3%). All isolates were susceptible to itraconazole and voriconazole. The literature review showed documented evidence of triazole-resistant Aspergillus species from East and West Africa. CONCLUSIONS: We found no triazole resistance in environmental isolates of Aspergillus in Lagos, Nigeria. Nevertheless, regular surveillance in clinical and environmental isolates is necessary in the light of findings from other African studies.
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spelling pubmed-84389392021-09-15 Triazole susceptibility of Aspergillus species: environmental survey in Lagos, Nigeria and review of the rest of Africa Campbell, Cynthia Abosede Osaigbovo, Iriagbonse Iyabo Oladele, Rita Okeoghene Ther Adv Infect Dis Fungal Diseases in Africa: Epidemiologic, Diagnostic and Therapeutic Advances BACKGROUND: Triazole resistance is an emerging problem in the management of human aspergillosis globally and can arise in Aspergillus species which have been exposed to azole fungicides in the environment. We surveyed local government and council development areas in Lagos, Nigeria, to determine the distribution of Aspergillus species in the environment and their susceptibility to locally available triazole antifungal agents. We also reviewed the literature on the subject from the rest of Africa. METHODS: A total of 168 soil samples from six locations in Lagos, Nigeria were processed and cultured on Saboraud dextrose agar impregnated with chloramphenicol to isolate Aspergillus species. Isolates were tested for susceptibility to itraconazole and voriconazole by microbroth dilution according to the European Committee on Antimicrobial Susceptibility Testing reference method. Relevant databases were searched to identify published work pertaining to triazole susceptibility of Aspergillus species in Africa. RESULTS: A total of 117 Aspergillus species were isolated. Aspergillus niger was the most frequently isolated species (42.7%). Other species isolated were Aspergillus flavus, 37 (31.6%), Aspergillus terreus, 20 (17.1%), Aspergillus fumigatus, 5 (4.3%) and Aspergillus nidulans, 5 (4.3%). All isolates were susceptible to itraconazole and voriconazole. The literature review showed documented evidence of triazole-resistant Aspergillus species from East and West Africa. CONCLUSIONS: We found no triazole resistance in environmental isolates of Aspergillus in Lagos, Nigeria. Nevertheless, regular surveillance in clinical and environmental isolates is necessary in the light of findings from other African studies. SAGE Publications 2021-09-12 /pmc/articles/PMC8438939/ /pubmed/34532039 http://dx.doi.org/10.1177/20499361211044330 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Fungal Diseases in Africa: Epidemiologic, Diagnostic and Therapeutic Advances
Campbell, Cynthia Abosede
Osaigbovo, Iriagbonse Iyabo
Oladele, Rita Okeoghene
Triazole susceptibility of Aspergillus species: environmental survey in Lagos, Nigeria and review of the rest of Africa
title Triazole susceptibility of Aspergillus species: environmental survey in Lagos, Nigeria and review of the rest of Africa
title_full Triazole susceptibility of Aspergillus species: environmental survey in Lagos, Nigeria and review of the rest of Africa
title_fullStr Triazole susceptibility of Aspergillus species: environmental survey in Lagos, Nigeria and review of the rest of Africa
title_full_unstemmed Triazole susceptibility of Aspergillus species: environmental survey in Lagos, Nigeria and review of the rest of Africa
title_short Triazole susceptibility of Aspergillus species: environmental survey in Lagos, Nigeria and review of the rest of Africa
title_sort triazole susceptibility of aspergillus species: environmental survey in lagos, nigeria and review of the rest of africa
topic Fungal Diseases in Africa: Epidemiologic, Diagnostic and Therapeutic Advances
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438939/
https://www.ncbi.nlm.nih.gov/pubmed/34532039
http://dx.doi.org/10.1177/20499361211044330
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