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Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance

Fibroblast growth factor 21 (FGF21) has been identified as an important regulator of carbohydrate and lipid metabolism, which plays an important role for metabolic regulation, particularly under conditions of energy deprivation or stress conditions. Dairy cows are subjected to a negative energy bala...

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Autores principales: Eder, Klaus, Gessner, Denise K., Ringseis, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439079/
https://www.ncbi.nlm.nih.gov/pubmed/34517929
http://dx.doi.org/10.1186/s40104-021-00621-y
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author Eder, Klaus
Gessner, Denise K.
Ringseis, Robert
author_facet Eder, Klaus
Gessner, Denise K.
Ringseis, Robert
author_sort Eder, Klaus
collection PubMed
description Fibroblast growth factor 21 (FGF21) has been identified as an important regulator of carbohydrate and lipid metabolism, which plays an important role for metabolic regulation, particularly under conditions of energy deprivation or stress conditions. Dairy cows are subjected to a negative energy balance and various kinds of stress particularly during the periparturient phase and during early lactation. It has been shown that the plasma concentration of FGF21 in dairy cows is dramatically increased at parturition and remains high during the first weeks of lactation. This finding suggests that FGF21 might exert similar functions in dairy cows than in other species, such as mice or humans. However, the role of FGF21 in dairy cows has been less investigated so far. Following a brief summary of the previous findings about the function of FGF21 in humans and mice, the present review aims to present the current state of knowledge about the role of FGF21 in dairy cows. The first part of the review deals with the tissue localization of FGF21 and with conditions leading to an upregulation of FGF21 expression in the liver of dairy cows. In the second part, the influence of nutrition on FGF21 expression and the role of FGF21 for metabolic diseases in dairy cows is addressed. In the third part, findings of exogenous FGF21 application on metabolism in dairy cows are reported. Finally, the potential relevance of FGF21 in dairy cows is discussed. It is concluded that FGF21 might be of great importance for metabolic adaptation to negative energy balance and stress conditions in dairy cows. However, further studies are needed for a better understanding of the functions of FGF21 in dairy cows.
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spelling pubmed-84390792021-09-14 Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance Eder, Klaus Gessner, Denise K. Ringseis, Robert J Anim Sci Biotechnol Review Fibroblast growth factor 21 (FGF21) has been identified as an important regulator of carbohydrate and lipid metabolism, which plays an important role for metabolic regulation, particularly under conditions of energy deprivation or stress conditions. Dairy cows are subjected to a negative energy balance and various kinds of stress particularly during the periparturient phase and during early lactation. It has been shown that the plasma concentration of FGF21 in dairy cows is dramatically increased at parturition and remains high during the first weeks of lactation. This finding suggests that FGF21 might exert similar functions in dairy cows than in other species, such as mice or humans. However, the role of FGF21 in dairy cows has been less investigated so far. Following a brief summary of the previous findings about the function of FGF21 in humans and mice, the present review aims to present the current state of knowledge about the role of FGF21 in dairy cows. The first part of the review deals with the tissue localization of FGF21 and with conditions leading to an upregulation of FGF21 expression in the liver of dairy cows. In the second part, the influence of nutrition on FGF21 expression and the role of FGF21 for metabolic diseases in dairy cows is addressed. In the third part, findings of exogenous FGF21 application on metabolism in dairy cows are reported. Finally, the potential relevance of FGF21 in dairy cows is discussed. It is concluded that FGF21 might be of great importance for metabolic adaptation to negative energy balance and stress conditions in dairy cows. However, further studies are needed for a better understanding of the functions of FGF21 in dairy cows. BioMed Central 2021-09-14 /pmc/articles/PMC8439079/ /pubmed/34517929 http://dx.doi.org/10.1186/s40104-021-00621-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Eder, Klaus
Gessner, Denise K.
Ringseis, Robert
Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance
title Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance
title_full Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance
title_fullStr Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance
title_full_unstemmed Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance
title_short Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance
title_sort fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439079/
https://www.ncbi.nlm.nih.gov/pubmed/34517929
http://dx.doi.org/10.1186/s40104-021-00621-y
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