Quantification of cognitive impairment to characterize heterogeneity of patients at risk of developing Alzheimer's disease dementia

INTRODUCTION: Neuropsychological test scores are limited and standard outcomes may mask the heterogeneity of cognitive impairment. This article presents the calculation and evaluation of six composite scores that quantify domain‐specific impairment. METHODS: Parameters for composite scores calculation were learned by performing confirmatory factor analysis in a sample of participants from the Alzheimer's Disease Neuroimaging Initiative database. The obtained scores were evaluated with a separate sample of mild cognitive impairment (MCI) in two automated tasks: unsupervised partition in different subgroups and prediction of progression to dementia for different time windows. RESULTS: MCI subgroups with distinctive cognitive profiles and risk of progression emerged from cluster analysis. Composite scores outperform standard neuropsychological tests when automatically predicting progression within time windows up to 5 years. CONCLUSIONS: Domain‐specific composite scores are useful to delineate profiles of impairment, stratify the MCI risk, and predict progression to dementia.