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Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mouse Pancreas in a Gender-Specific Manner
Mounting evidence has shown that intrauterine hyperglycemia exposure during critical stages of development may be contributing to the increasing prevalence of diabetes. However, little is known about the mechanisms responsible for offspring metabolic disorder. In this present study, we explored intr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439196/ https://www.ncbi.nlm.nih.gov/pubmed/34531826 http://dx.doi.org/10.3389/fendo.2021.710221 |
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author | Zhu, Hong Luo, Si-Si Cheng, Yi Yan, Yi-Shang Zou, Ke-Xin Ding, Guo-Lian Jin, Li Huang, He-Feng |
author_facet | Zhu, Hong Luo, Si-Si Cheng, Yi Yan, Yi-Shang Zou, Ke-Xin Ding, Guo-Lian Jin, Li Huang, He-Feng |
author_sort | Zhu, Hong |
collection | PubMed |
description | Mounting evidence has shown that intrauterine hyperglycemia exposure during critical stages of development may be contributing to the increasing prevalence of diabetes. However, little is known about the mechanisms responsible for offspring metabolic disorder. In this present study, we explored intrauterine hyperglycemia exposure on fetal pancreatic metabolome, and its potential link to impaired glucose tolerance in adult offspring. Here, using a GDM mouse model, we found the metabolome profiling of pancreas from male and female fetus showing altered metabolites in several important pathways, including 5-methylcytosine, α-KG, branched-chain amino acids, and cystine, which are associated with epigenetic modification, insulin secretion, and intracellular redox status, respectively. This finding suggests that intrauterine exposure to hyperglycemia could cause altered metabolome in pancreas, which might be a metabolism-mediated mechanism for GDM-induced intergenerational diabetes predisposition. |
format | Online Article Text |
id | pubmed-8439196 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84391962021-09-15 Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mouse Pancreas in a Gender-Specific Manner Zhu, Hong Luo, Si-Si Cheng, Yi Yan, Yi-Shang Zou, Ke-Xin Ding, Guo-Lian Jin, Li Huang, He-Feng Front Endocrinol (Lausanne) Endocrinology Mounting evidence has shown that intrauterine hyperglycemia exposure during critical stages of development may be contributing to the increasing prevalence of diabetes. However, little is known about the mechanisms responsible for offspring metabolic disorder. In this present study, we explored intrauterine hyperglycemia exposure on fetal pancreatic metabolome, and its potential link to impaired glucose tolerance in adult offspring. Here, using a GDM mouse model, we found the metabolome profiling of pancreas from male and female fetus showing altered metabolites in several important pathways, including 5-methylcytosine, α-KG, branched-chain amino acids, and cystine, which are associated with epigenetic modification, insulin secretion, and intracellular redox status, respectively. This finding suggests that intrauterine exposure to hyperglycemia could cause altered metabolome in pancreas, which might be a metabolism-mediated mechanism for GDM-induced intergenerational diabetes predisposition. Frontiers Media S.A. 2021-08-31 /pmc/articles/PMC8439196/ /pubmed/34531826 http://dx.doi.org/10.3389/fendo.2021.710221 Text en Copyright © 2021 Zhu, Luo, Cheng, Yan, Zou, Ding, Jin and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Zhu, Hong Luo, Si-Si Cheng, Yi Yan, Yi-Shang Zou, Ke-Xin Ding, Guo-Lian Jin, Li Huang, He-Feng Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mouse Pancreas in a Gender-Specific Manner |
title | Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mouse Pancreas in a Gender-Specific Manner |
title_full | Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mouse Pancreas in a Gender-Specific Manner |
title_fullStr | Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mouse Pancreas in a Gender-Specific Manner |
title_full_unstemmed | Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mouse Pancreas in a Gender-Specific Manner |
title_short | Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mouse Pancreas in a Gender-Specific Manner |
title_sort | intrauterine hyperglycemia alters the metabolomic profile in fetal mouse pancreas in a gender-specific manner |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439196/ https://www.ncbi.nlm.nih.gov/pubmed/34531826 http://dx.doi.org/10.3389/fendo.2021.710221 |
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