Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19

AIM: This study aimed to investigate whether serum biochemical parameters can be used as a surrogate for chest computed tomography (CT) in the diagnosis of COVID-19 in pediatric patients. MATERIALS & METHODS: We evaluated potential associations between various serum biochemical markers and the C...

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Autores principales: Das, Karuna M, Singh, Rajvir, Subramanya, Sandeep, Ojha, Shreesh Kumar, Almansoori, Taleb, Gokhale, Dilip, Alkoteesh, Jamal Aldeen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439343/
https://www.ncbi.nlm.nih.gov/pubmed/34539810
http://dx.doi.org/10.2217/fvl-2021-0118
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author Das, Karuna M
Singh, Rajvir
Subramanya, Sandeep
Ojha, Shreesh Kumar
Almansoori, Taleb
Gokhale, Dilip
Alkoteesh, Jamal Aldeen
author_facet Das, Karuna M
Singh, Rajvir
Subramanya, Sandeep
Ojha, Shreesh Kumar
Almansoori, Taleb
Gokhale, Dilip
Alkoteesh, Jamal Aldeen
author_sort Das, Karuna M
collection PubMed
description AIM: This study aimed to investigate whether serum biochemical parameters can be used as a surrogate for chest computed tomography (CT) in the diagnosis of COVID-19 in pediatric patients. MATERIALS & METHODS: We evaluated potential associations between various serum biochemical markers and the COVID-reporting and data system (RADS) pneumonia grading system in 53 individuals with confirmed COVID-19. RESULTS: A total of 28 chest CT scans (52.8%) were abnormal. Patients with confirmed COVID-19 on CT showed a statistically significant increase in lactate dehydrogenase (186.4 ± 56.5 vs 228.4 ± 60.6; p = 0.01), which was significantly correlated with the COVID-RADS pneumonia grading system. CONCLUSION: Lactate dehydrogenase can be used as a surrogate marker for chest CT in children with COVID-19. This can reduce exposure to ionizing radiation during initial diagnostic procedures in children with suspected COVID-19 pneumonia.
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spelling pubmed-84393432021-09-15 Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19 Das, Karuna M Singh, Rajvir Subramanya, Sandeep Ojha, Shreesh Kumar Almansoori, Taleb Gokhale, Dilip Alkoteesh, Jamal Aldeen Future Virol Short Communication AIM: This study aimed to investigate whether serum biochemical parameters can be used as a surrogate for chest computed tomography (CT) in the diagnosis of COVID-19 in pediatric patients. MATERIALS & METHODS: We evaluated potential associations between various serum biochemical markers and the COVID-reporting and data system (RADS) pneumonia grading system in 53 individuals with confirmed COVID-19. RESULTS: A total of 28 chest CT scans (52.8%) were abnormal. Patients with confirmed COVID-19 on CT showed a statistically significant increase in lactate dehydrogenase (186.4 ± 56.5 vs 228.4 ± 60.6; p = 0.01), which was significantly correlated with the COVID-RADS pneumonia grading system. CONCLUSION: Lactate dehydrogenase can be used as a surrogate marker for chest CT in children with COVID-19. This can reduce exposure to ionizing radiation during initial diagnostic procedures in children with suspected COVID-19 pneumonia. Future Medicine Ltd 2021-09-02 2021-09 /pmc/articles/PMC8439343/ /pubmed/34539810 http://dx.doi.org/10.2217/fvl-2021-0118 Text en © 2021 Future Medicine Ltd https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Short Communication
Das, Karuna M
Singh, Rajvir
Subramanya, Sandeep
Ojha, Shreesh Kumar
Almansoori, Taleb
Gokhale, Dilip
Alkoteesh, Jamal Aldeen
Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19
title Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19
title_full Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19
title_fullStr Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19
title_full_unstemmed Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19
title_short Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19
title_sort serum biochemical parameters as a surrogate marker for chest computed tomography in children with covid-19
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439343/
https://www.ncbi.nlm.nih.gov/pubmed/34539810
http://dx.doi.org/10.2217/fvl-2021-0118
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