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A national survey of antibacterial consumption in Sri Lanka

INTRODUCTION: Optimizing the use of antibacterial medicines is an accepted strategy to combat the antibacterial resistance. Availability of reliable antibacterial consumption (ABC) data is a prerequisite to implement this strategy. OBJECTIVES: To quantify and describe the national ABC in Sri Lanka a...

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Autores principales: Sri Ranganathan, Shalini, Wanigatunge, Chandanie, Senadheera, G. P. S. G., Beneragama, B. V. S. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439449/
https://www.ncbi.nlm.nih.gov/pubmed/34520501
http://dx.doi.org/10.1371/journal.pone.0257424
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author Sri Ranganathan, Shalini
Wanigatunge, Chandanie
Senadheera, G. P. S. G.
Beneragama, B. V. S. H.
author_facet Sri Ranganathan, Shalini
Wanigatunge, Chandanie
Senadheera, G. P. S. G.
Beneragama, B. V. S. H.
author_sort Sri Ranganathan, Shalini
collection PubMed
description INTRODUCTION: Optimizing the use of antibacterial medicines is an accepted strategy to combat the antibacterial resistance. Availability of reliable antibacterial consumption (ABC) data is a prerequisite to implement this strategy. OBJECTIVES: To quantify and describe the national ABC in Sri Lanka and to examine any differences in the consumption between public and private sector. METHODS: The methodology for this survey was adapted from World Health Organization (WHO) methodology for a global programme on surveillance of antimicrobial consumption. Aggregate data on national consumption of systemic antibacterials (J01- Anatomical Therapeutic Chemical Classification (ATC) for 2017 were retrospectively extracted from all available data sources and classified using ATC classification. Quantity of consumption was converted to Defined Daily Doses (DDDs). Data are presented as total consumption and comparison between the public and private sector. Selected key quality indicators of ABC were compared between these two sectors. FINDINGS: From the available data sources, the total ABC in 2017 was 343.46 million DDDs. Private sector consumption accounted for 246.76 million DDDs compared to 97.96 million DDDs distributed to entire public sector by the Ministry of Health. Beta-lactam-penicillins antibacterial group accounted for 58.79% in public sector compared to 27.48% in private sector while macrolides, quinolones and other beta-lactam antibacterials accounted for 60.51% in the private compared to 28.41% in public sector. Consumption of Reserve group antibacterials was negligible, and limited to private sector. Watch category antibacterials accounted for 46%, 24% and 54% of the total, public and private sector consumption, respectively. CONCLUSIONS: A disproportionately higher use of broad spectrum and Watch category antibacterials was observed in the private sector which needs further study. This national consumption survey highlights the need and provides the opening for establishment of ABC surveillance in Sri Lanka.
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spelling pubmed-84394492021-09-15 A national survey of antibacterial consumption in Sri Lanka Sri Ranganathan, Shalini Wanigatunge, Chandanie Senadheera, G. P. S. G. Beneragama, B. V. S. H. PLoS One Research Article INTRODUCTION: Optimizing the use of antibacterial medicines is an accepted strategy to combat the antibacterial resistance. Availability of reliable antibacterial consumption (ABC) data is a prerequisite to implement this strategy. OBJECTIVES: To quantify and describe the national ABC in Sri Lanka and to examine any differences in the consumption between public and private sector. METHODS: The methodology for this survey was adapted from World Health Organization (WHO) methodology for a global programme on surveillance of antimicrobial consumption. Aggregate data on national consumption of systemic antibacterials (J01- Anatomical Therapeutic Chemical Classification (ATC) for 2017 were retrospectively extracted from all available data sources and classified using ATC classification. Quantity of consumption was converted to Defined Daily Doses (DDDs). Data are presented as total consumption and comparison between the public and private sector. Selected key quality indicators of ABC were compared between these two sectors. FINDINGS: From the available data sources, the total ABC in 2017 was 343.46 million DDDs. Private sector consumption accounted for 246.76 million DDDs compared to 97.96 million DDDs distributed to entire public sector by the Ministry of Health. Beta-lactam-penicillins antibacterial group accounted for 58.79% in public sector compared to 27.48% in private sector while macrolides, quinolones and other beta-lactam antibacterials accounted for 60.51% in the private compared to 28.41% in public sector. Consumption of Reserve group antibacterials was negligible, and limited to private sector. Watch category antibacterials accounted for 46%, 24% and 54% of the total, public and private sector consumption, respectively. CONCLUSIONS: A disproportionately higher use of broad spectrum and Watch category antibacterials was observed in the private sector which needs further study. This national consumption survey highlights the need and provides the opening for establishment of ABC surveillance in Sri Lanka. Public Library of Science 2021-09-14 /pmc/articles/PMC8439449/ /pubmed/34520501 http://dx.doi.org/10.1371/journal.pone.0257424 Text en © 2021 Sri Ranganathan et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sri Ranganathan, Shalini
Wanigatunge, Chandanie
Senadheera, G. P. S. G.
Beneragama, B. V. S. H.
A national survey of antibacterial consumption in Sri Lanka
title A national survey of antibacterial consumption in Sri Lanka
title_full A national survey of antibacterial consumption in Sri Lanka
title_fullStr A national survey of antibacterial consumption in Sri Lanka
title_full_unstemmed A national survey of antibacterial consumption in Sri Lanka
title_short A national survey of antibacterial consumption in Sri Lanka
title_sort national survey of antibacterial consumption in sri lanka
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439449/
https://www.ncbi.nlm.nih.gov/pubmed/34520501
http://dx.doi.org/10.1371/journal.pone.0257424
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