A murine model of the human CREBRF(R457Q) obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress

Obesity and diabetes have strong heritable components, yet the genetic contributions to these diseases remain largely unexplained. In humans, a missense variant in Creb3 regulatory factor (CREBRF) [rs373863828 (p.Arg457Gln); CREBRF(R457Q)] is strongly associated with increased odds of obesity but de...

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Detalles Bibliográficos
Autores principales: Kanshana, Jitendra S., Mattila, Polly E., Ewing, Michael C., Wood, Ashlee N., Schoiswohl, Gabriele, Meyer, Anna C., Kowalski, Aneta, Rosenthal, Samantha L., Gingras, Sebastien, Kaufman, Brett A., Lu, Ray, Weeks, Daniel E., McGarvey, Stephen T., Minster, Ryan L., Hawley, Nicola L., Kershaw, Erin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439463/
https://www.ncbi.nlm.nih.gov/pubmed/34520472
http://dx.doi.org/10.1371/journal.pone.0251895

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