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Cancer associated mutations in Sec61γ alter the permeability of the ER translocase

Translocation of secretory and integral membrane proteins across or into the ER membrane occurs via the Sec61 complex, a heterotrimeric protein complex possessing two essential sub-units, Sec61p/Sec61α and Sss1p/Sec61γ and the non-essential Sbh1p/Sec61β subunit. In addition to forming a protein cond...

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Detalles Bibliográficos
Autores principales:	Witham, Christopher M., Paxman, Aleshanee L., Baklous, Lamprini, Steuart, Robert F. L., Schulz, Benjamin L., Mousley, Carl J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439465/ https://www.ncbi.nlm.nih.gov/pubmed/34460824 http://dx.doi.org/10.1371/journal.pgen.1009780

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