High-throughput kinome-RNAi screen identifies protein kinase R activator (PACT) as a novel genetic modifier of CUG foci integrity in myotonic dystrophy type 1 (DM1)

Myotonic Dystrophy Type 1 (DM1) is the most common form of adult muscular dystrophy (~1:8000). In DM1, expansion of CTG trinucleotide repeats in the 3’ untranslated region of the dystrophia myotonica protein kinase (DMPK) gene results in DMPK mRNA hairpin structures which aggregate as insoluble ribo...

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Detalles Bibliográficos
Autores principales: Neault, Nafisa, O’Reilly, Sean, Baig, Aiman Tariq, Plaza-Diaz, Julio, Azimi, Mehrdad, Farooq, Faraz, Baird, Stephen D., MacKenzie, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439471/
https://www.ncbi.nlm.nih.gov/pubmed/34520479
http://dx.doi.org/10.1371/journal.pone.0256276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439471/
https://www.ncbi.nlm.nih.gov/pubmed/34520479
http://dx.doi.org/10.1371/journal.pone.0256276

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