Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype

Several lines of study suggest that peripheral metabolism of amyloid beta (Aß) is associated with risk for Alzheimer disease (AD). In blood, greater than 90% of Aß is complexed as an apolipoprotein, raising the possibility of a lipoprotein-mediated axis for AD risk. In this study, we report that gen...

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Detalles Bibliográficos
Autores principales: Lam, Virginie, Takechi, Ryusuke, Hackett, Mark J., Francis, Roslyn, Bynevelt, Michael, Celliers, Liesl M., Nesbit, Michael, Mamsa, Somayra, Arfuso, Frank, Das, Sukanya, Koentgen, Frank, Hagan, Maree, Codd, Lincoln, Richardson, Kirsty, O’Mara, Brenton, Scharli, Rainer K., Morandeau, Laurence, Gauntlett, Jonathan, Leatherday, Christopher, Boucek, Jan, Mamo, John C. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439475/
https://www.ncbi.nlm.nih.gov/pubmed/34520451
http://dx.doi.org/10.1371/journal.pbio.3001358

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