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Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention

OBJECTIVES: Reactive oxygen species generated by xanthine oxidoreductase (XOR) are associated with the progression of atherosclerosis. However, changes in plasma XOR (pXOR) activity after percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) remains unknown. METHODS: Here...

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Autores principales: Sato, Ryota, Akita, Keitaro, Ikoma, Takenori, Iguchi, Keisuke, Murase, Takayo, Nakamura, Takashi, Akari, Seigo, Mogi, Satoshi, Naruse, Yoshihisa, Ohtani, Hayato, Maekawa, Yuichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439489/
https://www.ncbi.nlm.nih.gov/pubmed/34520495
http://dx.doi.org/10.1371/journal.pone.0257227
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author Sato, Ryota
Akita, Keitaro
Ikoma, Takenori
Iguchi, Keisuke
Murase, Takayo
Nakamura, Takashi
Akari, Seigo
Mogi, Satoshi
Naruse, Yoshihisa
Ohtani, Hayato
Maekawa, Yuichiro
author_facet Sato, Ryota
Akita, Keitaro
Ikoma, Takenori
Iguchi, Keisuke
Murase, Takayo
Nakamura, Takashi
Akari, Seigo
Mogi, Satoshi
Naruse, Yoshihisa
Ohtani, Hayato
Maekawa, Yuichiro
author_sort Sato, Ryota
collection PubMed
description OBJECTIVES: Reactive oxygen species generated by xanthine oxidoreductase (XOR) are associated with the progression of atherosclerosis. However, changes in plasma XOR (pXOR) activity after percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) remains unknown. METHODS: Herein, we compared the change in the pXOR activity in patients undergoing PCI with that in patients undergoing coronary angiography (CAG) and further evaluated the relation between changes in pXOR activity and in-hospital and long-term outcomes of patients undergoing PCI. The pXOR activity of 80 consecutive patients who underwent PCI and 25 patients who underwent CAG during the hospitalization was analyzed daily. The percentage changes from baseline regulated time interval was evaluated. RESULTS: We found that although pXOR activity decreased after PCI, and remained low until discharge, no significant changes were observed in patients undergoing CAG. Furthermore, among the patients undergoing PCI, those who experienced in-hospital adverse events, had a higher percentage of pXOR reduction 3 days after PCI. There was no association between these changes and long-term events. CONCLUSIONS: A significant change in pXOR activity was observed in patients undergoing PCI than in patients undergoing CAG, and there seems to be a correlation between the in-hospital outcomes and the percentage reduction from baseline in pXOR activity.
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spelling pubmed-84394892021-09-15 Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention Sato, Ryota Akita, Keitaro Ikoma, Takenori Iguchi, Keisuke Murase, Takayo Nakamura, Takashi Akari, Seigo Mogi, Satoshi Naruse, Yoshihisa Ohtani, Hayato Maekawa, Yuichiro PLoS One Research Article OBJECTIVES: Reactive oxygen species generated by xanthine oxidoreductase (XOR) are associated with the progression of atherosclerosis. However, changes in plasma XOR (pXOR) activity after percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) remains unknown. METHODS: Herein, we compared the change in the pXOR activity in patients undergoing PCI with that in patients undergoing coronary angiography (CAG) and further evaluated the relation between changes in pXOR activity and in-hospital and long-term outcomes of patients undergoing PCI. The pXOR activity of 80 consecutive patients who underwent PCI and 25 patients who underwent CAG during the hospitalization was analyzed daily. The percentage changes from baseline regulated time interval was evaluated. RESULTS: We found that although pXOR activity decreased after PCI, and remained low until discharge, no significant changes were observed in patients undergoing CAG. Furthermore, among the patients undergoing PCI, those who experienced in-hospital adverse events, had a higher percentage of pXOR reduction 3 days after PCI. There was no association between these changes and long-term events. CONCLUSIONS: A significant change in pXOR activity was observed in patients undergoing PCI than in patients undergoing CAG, and there seems to be a correlation between the in-hospital outcomes and the percentage reduction from baseline in pXOR activity. Public Library of Science 2021-09-14 /pmc/articles/PMC8439489/ /pubmed/34520495 http://dx.doi.org/10.1371/journal.pone.0257227 Text en © 2021 Sato et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sato, Ryota
Akita, Keitaro
Ikoma, Takenori
Iguchi, Keisuke
Murase, Takayo
Nakamura, Takashi
Akari, Seigo
Mogi, Satoshi
Naruse, Yoshihisa
Ohtani, Hayato
Maekawa, Yuichiro
Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention
title Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention
title_full Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention
title_fullStr Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention
title_full_unstemmed Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention
title_short Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention
title_sort association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439489/
https://www.ncbi.nlm.nih.gov/pubmed/34520495
http://dx.doi.org/10.1371/journal.pone.0257227
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