Morphine promotes microglial activation by upregulating the EGFR/ERK signaling pathway

Although they represent the cornerstone of analgesic therapy, opioids, such as morphine, are limited in efficacy by drug tolerance, hyperalgesia and other side effects. Activation of microglia and the consequent production of proinflammatory cytokines play a key pathogenic role in morphine tolerance...

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Detalles Bibliográficos
Autores principales: Yang, Yaqiong, Sun, Yu, Hu, Rong, Yan, Jia, Wang, Ziheng, Li, Wenlong, Jiang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439491/
https://www.ncbi.nlm.nih.gov/pubmed/34520454
http://dx.doi.org/10.1371/journal.pone.0256870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439491/
https://www.ncbi.nlm.nih.gov/pubmed/34520454
http://dx.doi.org/10.1371/journal.pone.0256870

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