High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs

Cancer patients exhibit a broad range of inter-individual variability in response and toxicity to widely used anticancer drugs, and genetic variation is a major contributor to this variability. To identify new genes that influence the response of 44 FDA-approved anticancer drug treatments widely use...

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Detalles Bibliográficos
Autores principales: Akhtari, Farida S., Green, Adrian J., Small, George W., Havener, Tammy M., House, John S., Roell, Kyle R., Reif, David M., McLeod, Howard L., Wiltshire, Timothy, Motsinger-Reif, Alison A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439493/
https://www.ncbi.nlm.nih.gov/pubmed/34437536
http://dx.doi.org/10.1371/journal.pgen.1009732

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