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Is adiposity associated with back and lower limb pain? A systematic review
BACKGROUND: Back and lower limb pain have a major impact on physical function and quality of life. While obesity is a modifiable risk factor for musculoskeletal pain, the role of adiposity is less clear. This systematic review aimed to examine the relationship between both adiposity and its distribu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439494/ https://www.ncbi.nlm.nih.gov/pubmed/34520462 http://dx.doi.org/10.1371/journal.pone.0256720 |
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author | Peiris, Waruna L. Cicuttini, Flavia M. Hussain, Sultana Monira Estee, Mahnuma M. Romero, Lorena Ranger, Tom A. Fairley, Jessica L. McLean, Emily C. Urquhart, Donna M. |
author_facet | Peiris, Waruna L. Cicuttini, Flavia M. Hussain, Sultana Monira Estee, Mahnuma M. Romero, Lorena Ranger, Tom A. Fairley, Jessica L. McLean, Emily C. Urquhart, Donna M. |
author_sort | Peiris, Waruna L. |
collection | PubMed |
description | BACKGROUND: Back and lower limb pain have a major impact on physical function and quality of life. While obesity is a modifiable risk factor for musculoskeletal pain, the role of adiposity is less clear. This systematic review aimed to examine the relationship between both adiposity and its distribution and back and lower limb pain. METHODS: A systematic search of electronic databases was conducted to identify studies that examined the association between anthropometric and/or direct measures of adiposity and site specific musculoskeletal pain. Risk of bias was assessed and a best evidence synthesis was performed. RESULTS: A total of 56 studies were identified which examined 4 pain regions, including the lower back (36 studies), hip (two studies), knee (13 studies) and foot (eight studies). 31(55%) studies were assessed as having low to moderate risk of bias. 17(30%) studies were cohort in design. The best evidence synthesis provided evidence of a relationship between central adiposity and low back and knee pain, but not hip or foot pain. There was also evidence of a longitudinal relationship between adiposity and the presence of back, knee and foot pain, as well as incident and increasing foot pain. CONCLUSIONS: This systematic review provides evidence of an association between both body fat and its central distribution and low back and knee pain, and a longitudinal relationship between adiposity and back, knee and foot pain. These results highlight the potential for targeting adiposity in the development of novel treatments at these sites. |
format | Online Article Text |
id | pubmed-8439494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-84394942021-09-15 Is adiposity associated with back and lower limb pain? A systematic review Peiris, Waruna L. Cicuttini, Flavia M. Hussain, Sultana Monira Estee, Mahnuma M. Romero, Lorena Ranger, Tom A. Fairley, Jessica L. McLean, Emily C. Urquhart, Donna M. PLoS One Research Article BACKGROUND: Back and lower limb pain have a major impact on physical function and quality of life. While obesity is a modifiable risk factor for musculoskeletal pain, the role of adiposity is less clear. This systematic review aimed to examine the relationship between both adiposity and its distribution and back and lower limb pain. METHODS: A systematic search of electronic databases was conducted to identify studies that examined the association between anthropometric and/or direct measures of adiposity and site specific musculoskeletal pain. Risk of bias was assessed and a best evidence synthesis was performed. RESULTS: A total of 56 studies were identified which examined 4 pain regions, including the lower back (36 studies), hip (two studies), knee (13 studies) and foot (eight studies). 31(55%) studies were assessed as having low to moderate risk of bias. 17(30%) studies were cohort in design. The best evidence synthesis provided evidence of a relationship between central adiposity and low back and knee pain, but not hip or foot pain. There was also evidence of a longitudinal relationship between adiposity and the presence of back, knee and foot pain, as well as incident and increasing foot pain. CONCLUSIONS: This systematic review provides evidence of an association between both body fat and its central distribution and low back and knee pain, and a longitudinal relationship between adiposity and back, knee and foot pain. These results highlight the potential for targeting adiposity in the development of novel treatments at these sites. Public Library of Science 2021-09-14 /pmc/articles/PMC8439494/ /pubmed/34520462 http://dx.doi.org/10.1371/journal.pone.0256720 Text en © 2021 Peiris et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Peiris, Waruna L. Cicuttini, Flavia M. Hussain, Sultana Monira Estee, Mahnuma M. Romero, Lorena Ranger, Tom A. Fairley, Jessica L. McLean, Emily C. Urquhart, Donna M. Is adiposity associated with back and lower limb pain? A systematic review |
title | Is adiposity associated with back and lower limb pain? A systematic review |
title_full | Is adiposity associated with back and lower limb pain? A systematic review |
title_fullStr | Is adiposity associated with back and lower limb pain? A systematic review |
title_full_unstemmed | Is adiposity associated with back and lower limb pain? A systematic review |
title_short | Is adiposity associated with back and lower limb pain? A systematic review |
title_sort | is adiposity associated with back and lower limb pain? a systematic review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439494/ https://www.ncbi.nlm.nih.gov/pubmed/34520462 http://dx.doi.org/10.1371/journal.pone.0256720 |
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