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Is adiposity associated with back and lower limb pain? A systematic review

BACKGROUND: Back and lower limb pain have a major impact on physical function and quality of life. While obesity is a modifiable risk factor for musculoskeletal pain, the role of adiposity is less clear. This systematic review aimed to examine the relationship between both adiposity and its distribu...

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Autores principales: Peiris, Waruna L., Cicuttini, Flavia M., Hussain, Sultana Monira, Estee, Mahnuma M., Romero, Lorena, Ranger, Tom A., Fairley, Jessica L., McLean, Emily C., Urquhart, Donna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439494/
https://www.ncbi.nlm.nih.gov/pubmed/34520462
http://dx.doi.org/10.1371/journal.pone.0256720
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author Peiris, Waruna L.
Cicuttini, Flavia M.
Hussain, Sultana Monira
Estee, Mahnuma M.
Romero, Lorena
Ranger, Tom A.
Fairley, Jessica L.
McLean, Emily C.
Urquhart, Donna M.
author_facet Peiris, Waruna L.
Cicuttini, Flavia M.
Hussain, Sultana Monira
Estee, Mahnuma M.
Romero, Lorena
Ranger, Tom A.
Fairley, Jessica L.
McLean, Emily C.
Urquhart, Donna M.
author_sort Peiris, Waruna L.
collection PubMed
description BACKGROUND: Back and lower limb pain have a major impact on physical function and quality of life. While obesity is a modifiable risk factor for musculoskeletal pain, the role of adiposity is less clear. This systematic review aimed to examine the relationship between both adiposity and its distribution and back and lower limb pain. METHODS: A systematic search of electronic databases was conducted to identify studies that examined the association between anthropometric and/or direct measures of adiposity and site specific musculoskeletal pain. Risk of bias was assessed and a best evidence synthesis was performed. RESULTS: A total of 56 studies were identified which examined 4 pain regions, including the lower back (36 studies), hip (two studies), knee (13 studies) and foot (eight studies). 31(55%) studies were assessed as having low to moderate risk of bias. 17(30%) studies were cohort in design. The best evidence synthesis provided evidence of a relationship between central adiposity and low back and knee pain, but not hip or foot pain. There was also evidence of a longitudinal relationship between adiposity and the presence of back, knee and foot pain, as well as incident and increasing foot pain. CONCLUSIONS: This systematic review provides evidence of an association between both body fat and its central distribution and low back and knee pain, and a longitudinal relationship between adiposity and back, knee and foot pain. These results highlight the potential for targeting adiposity in the development of novel treatments at these sites.
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spelling pubmed-84394942021-09-15 Is adiposity associated with back and lower limb pain? A systematic review Peiris, Waruna L. Cicuttini, Flavia M. Hussain, Sultana Monira Estee, Mahnuma M. Romero, Lorena Ranger, Tom A. Fairley, Jessica L. McLean, Emily C. Urquhart, Donna M. PLoS One Research Article BACKGROUND: Back and lower limb pain have a major impact on physical function and quality of life. While obesity is a modifiable risk factor for musculoskeletal pain, the role of adiposity is less clear. This systematic review aimed to examine the relationship between both adiposity and its distribution and back and lower limb pain. METHODS: A systematic search of electronic databases was conducted to identify studies that examined the association between anthropometric and/or direct measures of adiposity and site specific musculoskeletal pain. Risk of bias was assessed and a best evidence synthesis was performed. RESULTS: A total of 56 studies were identified which examined 4 pain regions, including the lower back (36 studies), hip (two studies), knee (13 studies) and foot (eight studies). 31(55%) studies were assessed as having low to moderate risk of bias. 17(30%) studies were cohort in design. The best evidence synthesis provided evidence of a relationship between central adiposity and low back and knee pain, but not hip or foot pain. There was also evidence of a longitudinal relationship between adiposity and the presence of back, knee and foot pain, as well as incident and increasing foot pain. CONCLUSIONS: This systematic review provides evidence of an association between both body fat and its central distribution and low back and knee pain, and a longitudinal relationship between adiposity and back, knee and foot pain. These results highlight the potential for targeting adiposity in the development of novel treatments at these sites. Public Library of Science 2021-09-14 /pmc/articles/PMC8439494/ /pubmed/34520462 http://dx.doi.org/10.1371/journal.pone.0256720 Text en © 2021 Peiris et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Peiris, Waruna L.
Cicuttini, Flavia M.
Hussain, Sultana Monira
Estee, Mahnuma M.
Romero, Lorena
Ranger, Tom A.
Fairley, Jessica L.
McLean, Emily C.
Urquhart, Donna M.
Is adiposity associated with back and lower limb pain? A systematic review
title Is adiposity associated with back and lower limb pain? A systematic review
title_full Is adiposity associated with back and lower limb pain? A systematic review
title_fullStr Is adiposity associated with back and lower limb pain? A systematic review
title_full_unstemmed Is adiposity associated with back and lower limb pain? A systematic review
title_short Is adiposity associated with back and lower limb pain? A systematic review
title_sort is adiposity associated with back and lower limb pain? a systematic review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439494/
https://www.ncbi.nlm.nih.gov/pubmed/34520462
http://dx.doi.org/10.1371/journal.pone.0256720
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