Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

Mammalian cochlear outer hair cells (OHCs) are essential for hearing. Severe hearing impairment follows OHC degeneration. Previous attempts at regenerating new OHCs from cochlear supporting cells (SCs) have been unsuccessful, notably lacking expression of the key OHC motor protein, Prestin. Thus, re...

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Detalles Bibliográficos
Autores principales: Sun, Suhong, Li, Shuting, Luo, Zhengnan, Ren, Minhui, He, Shunji, Wang, Guangqin, Liu, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439656/
https://www.ncbi.nlm.nih.gov/pubmed/34477109
http://dx.doi.org/10.7554/eLife.66547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439656/
https://www.ncbi.nlm.nih.gov/pubmed/34477109
http://dx.doi.org/10.7554/eLife.66547

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