Cargando…

Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

Mammalian cochlear outer hair cells (OHCs) are essential for hearing. Severe hearing impairment follows OHC degeneration. Previous attempts at regenerating new OHCs from cochlear supporting cells (SCs) have been unsuccessful, notably lacking expression of the key OHC motor protein, Prestin. Thus, re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Suhong, Li, Shuting, Luo, Zhengnan, Ren, Minhui, He, Shunji, Wang, Guangqin, Liu, Zhiyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439656/ https://www.ncbi.nlm.nih.gov/pubmed/34477109 http://dx.doi.org/10.7554/eLife.66547

Ejemplares similares

Three distinct Atoh1 enhancers cooperate for sound receptor hair cell development
por: Luo, Zhengnan, et al.
Publicado: (2022)

Development and transdifferentiation into inner hair cells require Tbx2
por: Bi, Zhenghong, et al.
Publicado: (2022)

Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1
por: Jen, Hsin-I, et al.
Publicado: (2019)

Ikzf2/helios is a key transcriptional regulator of outer hair cell maturation
por: Chessum, Lauren, et al.
Publicado: (2018)

Neurog1, Neurod1, and Atoh1 are essential for spiral ganglia, cochlear nuclei, and cochlear hair cell development
por: Elliott, Karen L, et al.
Publicado: (2021)

The cochlear outer hair cell speed paradox
por: Rabbitt, Richard D.
Publicado: (2020)

A Nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells
por: Taiber, Shahar, et al.
Publicado: (2022)

Modulation of Outer Hair Cell Electromotility by Cochlear Supporting Cells and Gap Junctions
por: Yu, Ning, et al.
Publicado: (2009)

Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space
por: Babola, Travis A, et al.
Publicado: (2020)

Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1
por: Veithen, Mona, et al.
Publicado: (2023)

Comprehensive transcriptome analysis of cochlear spiral ganglion neurons at multiple ages
por: Li, Chao, et al.
Publicado: (2020)

Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance
por: Ciganović, Nikola, et al.
Publicado: (2017)

Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals
por: Iyer, Amrita A, et al.
Publicado: (2022)

The Kinocilia of Cochlear Hair Cells: Structures, Functions, and Diseases
por: Wang, Difei, et al.
Publicado: (2021)

Optimal Electrical Properties of Outer Hair Cells Ensure Cochlear Amplification
por: Nam, Jong-Hoon, et al.
Publicado: (2012)

Noise-induced Outer Hair Cells' Dysfunction and Cochlear Damage in Rabbits
por: Moussavi-Najarkola, S A, et al.
Publicado: (2012)

All Three Rows of Outer Hair Cells Are Required for Cochlear Amplification
por: Murakoshi, Michio, et al.
Publicado: (2015)

Cochlear Outer-Hair-Cell Power Generation and Viscous Fluid Loss
por: Wang, Yanli, et al.
Publicado: (2016)

Transcription Factors Expressed in Mouse Cochlear Inner and Outer Hair Cells
por: Li, Yi, et al.
Publicado: (2016)

The susceptibility of cochlear outer hair cells to cyclodextrin is not related to their electromotile activity
por: Zhou, Yingjie, et al.
Publicado: (2018)

Transcriptomes of cochlear inner and outer hair cells from adult mice
por: Li, Yi, et al.
Publicado: (2018)

A parametric blueprint for optimum cochlear outer hair cell design
por: Rabbitt, Richard D., et al.
Publicado: (2023)

Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
por: Brown, Tanya L, et al.
Publicado: (2023)

PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice
por: Li, Jie, et al.
Publicado: (2021)

In Vivo Generation of Immature Inner Hair Cells in Neonatal Mouse Cochleae by Ectopic Atoh1 Expression
por: Liu, Zhiyong, et al.
Publicado: (2014)

Dimensions of a Living Cochlear Hair Bundle
por: Miller, Katharine K., et al.
Publicado: (2021)

Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea
por: Lee, Sungsu, et al.
Publicado: (2017)

HIC1 Represses Atoh1 Transcription and Hair Cell Differentiation in the Cochlea
por: Abdul-Aziz, Dunia, et al.
Publicado: (2021)

Prestin-Driven Cochlear Amplification Is Not Limited by the Outer Hair Cell Membrane Time Constant
por: Johnson, Stuart L., et al.
Publicado: (2011)

Gentamicin Rapidly Inhibits Mitochondrial Metabolism in High-Frequency Cochlear Outer Hair Cells
por: Jensen-Smith, Heather C., et al.
Publicado: (2012)

Piezo1 haploinsufficiency does not alter mechanotransduction in mouse cochlear outer hair cells
por: Corns, Laura F., et al.
Publicado: (2016)

Loss of function of Ywhah in mice induces deafness and cochlear outer hair cell's degeneration
por: Buret, L, et al.
Publicado: (2016)

Loss of function of Ywhah in mice induces deafness and cochlear outer hair cells' degeneration
por: Buret, L, et al.
Publicado: (2016)

The contribution of TMC1 to adaptation of mechanoelectrical transduction channels in cochlear outer hair cells
por: Goldring, Adam C., et al.
Publicado: (2019)

Molecular and cytological profiling of biological aging of mouse cochlear inner and outer hair cells
por: Liu, Huizhan, et al.
Publicado: (2022)

Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells
por: Murtha, Kaitlin E., et al.
Publicado: (2022)

The Rho GTPase Cell Division Cycle 42 Regulates Stereocilia Development in Cochlear Hair Cells
por: Du, Haibo, et al.
Publicado: (2021)

Atoh1 expression levels define the fate of rat cochlear nonsensory epithelial cells in vitro
por: LUO, WEN-WEI, et al.
Publicado: (2014)

Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation
por: Lenz, Danielle R., et al.
Publicado: (2019)

Hair Cell Generation in Cochlear Culture Models Mediated by Novel γ-Secretase Inhibitors
por: Erni, Silvia T., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p0ajna12ii796bf49hs7tuogu7