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Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms
Coumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antivir...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440074/ https://www.ncbi.nlm.nih.gov/pubmed/34531939 http://dx.doi.org/10.1155/2021/6492346 |
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author | Sharifi-Rad, Javad Cruz-Martins, Natália López-Jornet, Pía Lopez, Eduardo Pons-Fuster Harun, Nidaa Yeskaliyeva, Balakyz Beyatli, Ahmet Sytar, Oksana Shaheen, Shabnum Sharopov, Farukh Taheri, Yasaman Docea, Anca Oana Calina, Daniela Cho, William C. |
author_facet | Sharifi-Rad, Javad Cruz-Martins, Natália López-Jornet, Pía Lopez, Eduardo Pons-Fuster Harun, Nidaa Yeskaliyeva, Balakyz Beyatli, Ahmet Sytar, Oksana Shaheen, Shabnum Sharopov, Farukh Taheri, Yasaman Docea, Anca Oana Calina, Daniela Cho, William C. |
author_sort | Sharifi-Rad, Javad |
collection | PubMed |
description | Coumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimer's disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensive. There are very few studies on the bioavailability of coumarins; therefore, further investigations are necessitated to study the bioavailability of different coumarins which already showed good biological activities in previous studies. On the evidence of varied pharmacological properties, the present work presents an overall review of the derivation, availability, and biological capacities of coumarins with further consideration of the essential mode of their therapeutic actions. In conclusion, a wide variety of coumarins are available, and their pharmacological activities are of current interest thanks to their synthetic accessibility and riches in medicinal plants. Coumarins perform the valuable function as therapeutic agents in a range of medical fields. |
format | Online Article Text |
id | pubmed-8440074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-84400742021-09-15 Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms Sharifi-Rad, Javad Cruz-Martins, Natália López-Jornet, Pía Lopez, Eduardo Pons-Fuster Harun, Nidaa Yeskaliyeva, Balakyz Beyatli, Ahmet Sytar, Oksana Shaheen, Shabnum Sharopov, Farukh Taheri, Yasaman Docea, Anca Oana Calina, Daniela Cho, William C. Oxid Med Cell Longev Review Article Coumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimer's disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensive. There are very few studies on the bioavailability of coumarins; therefore, further investigations are necessitated to study the bioavailability of different coumarins which already showed good biological activities in previous studies. On the evidence of varied pharmacological properties, the present work presents an overall review of the derivation, availability, and biological capacities of coumarins with further consideration of the essential mode of their therapeutic actions. In conclusion, a wide variety of coumarins are available, and their pharmacological activities are of current interest thanks to their synthetic accessibility and riches in medicinal plants. Coumarins perform the valuable function as therapeutic agents in a range of medical fields. Hindawi 2021-08-23 /pmc/articles/PMC8440074/ /pubmed/34531939 http://dx.doi.org/10.1155/2021/6492346 Text en Copyright © 2021 Javad Sharifi-Rad et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sharifi-Rad, Javad Cruz-Martins, Natália López-Jornet, Pía Lopez, Eduardo Pons-Fuster Harun, Nidaa Yeskaliyeva, Balakyz Beyatli, Ahmet Sytar, Oksana Shaheen, Shabnum Sharopov, Farukh Taheri, Yasaman Docea, Anca Oana Calina, Daniela Cho, William C. Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms |
title | Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms |
title_full | Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms |
title_fullStr | Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms |
title_full_unstemmed | Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms |
title_short | Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms |
title_sort | natural coumarins: exploring the pharmacological complexity and underlying molecular mechanisms |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440074/ https://www.ncbi.nlm.nih.gov/pubmed/34531939 http://dx.doi.org/10.1155/2021/6492346 |
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