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Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine

Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies. The mechanism underlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and parvalbumin (PV) neuronal dysfunction leading to disinhibition of mesostriatal dopamin...

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Detalles Bibliográficos
Autores principales:	Kokkinou, Michelle, Irvine, Elaine E., Bonsall, David R., Natesan, Sridhar, Wells, Lisa A., Smith, Mark, Glegola, Justyna, Paul, Eleanor J., Tossell, Kyoko, Veronese, Mattia, Khadayate, Sanjay, Dedic, Nina, Hopkins, Seth C., Ungless, Mark A., Withers, Dominic J., Howes, Oliver D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440182/ https://www.ncbi.nlm.nih.gov/pubmed/32382134 http://dx.doi.org/10.1038/s41380-020-0740-6

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