Immune imprinting and SARS-CoV-2 vaccine design

Reformulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines with variant strains is being pursued to combat the global surge in infections. We hypothesize that this may be suboptimal due to immune imprinting from earlier vaccination or infection with the original SARS-CoV-2 s...

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Autores principales: Wheatley, Adam K., Fox, Annette, Tan, Hyon-Xhi, Juno, Jennifer A., Davenport, Miles P., Subbarao, Kanta, Kent, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440232/
https://www.ncbi.nlm.nih.gov/pubmed/34580004
http://dx.doi.org/10.1016/j.it.2021.09.001
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author Wheatley, Adam K.
Fox, Annette
Tan, Hyon-Xhi
Juno, Jennifer A.
Davenport, Miles P.
Subbarao, Kanta
Kent, Stephen J.
author_facet Wheatley, Adam K.
Fox, Annette
Tan, Hyon-Xhi
Juno, Jennifer A.
Davenport, Miles P.
Subbarao, Kanta
Kent, Stephen J.
author_sort Wheatley, Adam K.
collection PubMed
description Reformulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines with variant strains is being pursued to combat the global surge in infections. We hypothesize that this may be suboptimal due to immune imprinting from earlier vaccination or infection with the original SARS-CoV-2 strain. New strategies may be needed to improve efficacy of SARS-CoV-2 variant vaccines.
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spelling pubmed-84402322021-09-15 Immune imprinting and SARS-CoV-2 vaccine design Wheatley, Adam K. Fox, Annette Tan, Hyon-Xhi Juno, Jennifer A. Davenport, Miles P. Subbarao, Kanta Kent, Stephen J. Trends Immunol Forum Reformulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines with variant strains is being pursued to combat the global surge in infections. We hypothesize that this may be suboptimal due to immune imprinting from earlier vaccination or infection with the original SARS-CoV-2 strain. New strategies may be needed to improve efficacy of SARS-CoV-2 variant vaccines. Elsevier Ltd. 2021-11 2021-09-15 /pmc/articles/PMC8440232/ /pubmed/34580004 http://dx.doi.org/10.1016/j.it.2021.09.001 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Forum
Wheatley, Adam K.
Fox, Annette
Tan, Hyon-Xhi
Juno, Jennifer A.
Davenport, Miles P.
Subbarao, Kanta
Kent, Stephen J.
Immune imprinting and SARS-CoV-2 vaccine design
title Immune imprinting and SARS-CoV-2 vaccine design
title_full Immune imprinting and SARS-CoV-2 vaccine design
title_fullStr Immune imprinting and SARS-CoV-2 vaccine design
title_full_unstemmed Immune imprinting and SARS-CoV-2 vaccine design
title_short Immune imprinting and SARS-CoV-2 vaccine design
title_sort immune imprinting and sars-cov-2 vaccine design
topic Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440232/
https://www.ncbi.nlm.nih.gov/pubmed/34580004
http://dx.doi.org/10.1016/j.it.2021.09.001
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