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Endocrine-related adverse events in a large series of cancer patients treated with anti-PD1 therapy
PURPOSE: Immune checkpoint inhibitors have opened a new scenario in the treatment of cancer. These agents can elicit adverse events, which may affect different systems and organs, including the endocrine system. The aims of this study were to evaluate the impact of the anti-PD-1 molecules nivolumab...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440282/ https://www.ncbi.nlm.nih.gov/pubmed/34036513 http://dx.doi.org/10.1007/s12020-021-02750-w |
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author | Rubino, Rossella Marini, Andrea Roviello, Giandomenico Presotto, Elena Margherita Desideri, Isacco Ciardetti, Isabella Brugia, Marco Pimpinelli, Nicola Antonuzzo, Lorenzo Mini, Enrico Livi, Lorenzo Maggi, Mario Peri, Alessandro |
author_facet | Rubino, Rossella Marini, Andrea Roviello, Giandomenico Presotto, Elena Margherita Desideri, Isacco Ciardetti, Isabella Brugia, Marco Pimpinelli, Nicola Antonuzzo, Lorenzo Mini, Enrico Livi, Lorenzo Maggi, Mario Peri, Alessandro |
author_sort | Rubino, Rossella |
collection | PubMed |
description | PURPOSE: Immune checkpoint inhibitors have opened a new scenario in the treatment of cancer. These agents can elicit adverse events, which may affect different systems and organs, including the endocrine system. The aims of this study were to evaluate the impact of the anti-PD-1 molecules nivolumab and pembrolizumab on endocrine toxicity and on patient outcome. METHODS: A retrospective and multicentre study was designed, which involved a total of 251 patients affected by different tumors (mostly non-small cell lung cancer, 68.92% and melanoma, 24.30%) and treated with the PD-1 inhibitors nivolumab (61.35%) or pembrolizumab (38.65%) for up to 60 months. Clinical and biochemical data were recorded until July 31, 2020. RESULTS: Endocrine toxicity occurred in 70 out of 251 patients (27.89%). It was mostly related to thyroid dysfunction and in 75% of cases occurred within 6 months from the beginning of therapy. A previous endocrine morbidity and female gender were predictors of endocrine toxicity. There was no association between endocrine dysfunction and patient outcome. However, when all toxicities (i.e., endocrine and non endocrine) were considered, a significant association with progression-free survival and overall survival was found. CONCLUSIONS: Thyroid alterations are frequently observed in cancer patients treated with anti PD-1 drugs, particularly in women and in the presence of a previous endocrinopathy. We suggest that regular thyroid assessment should be performed in these patients, especially in the first months of therapy. Finally, the onset of side effects, related to anti PD-1 agents, appears to be associated with a better outcome. |
format | Online Article Text |
id | pubmed-8440282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-84402822021-09-29 Endocrine-related adverse events in a large series of cancer patients treated with anti-PD1 therapy Rubino, Rossella Marini, Andrea Roviello, Giandomenico Presotto, Elena Margherita Desideri, Isacco Ciardetti, Isabella Brugia, Marco Pimpinelli, Nicola Antonuzzo, Lorenzo Mini, Enrico Livi, Lorenzo Maggi, Mario Peri, Alessandro Endocrine Original Article PURPOSE: Immune checkpoint inhibitors have opened a new scenario in the treatment of cancer. These agents can elicit adverse events, which may affect different systems and organs, including the endocrine system. The aims of this study were to evaluate the impact of the anti-PD-1 molecules nivolumab and pembrolizumab on endocrine toxicity and on patient outcome. METHODS: A retrospective and multicentre study was designed, which involved a total of 251 patients affected by different tumors (mostly non-small cell lung cancer, 68.92% and melanoma, 24.30%) and treated with the PD-1 inhibitors nivolumab (61.35%) or pembrolizumab (38.65%) for up to 60 months. Clinical and biochemical data were recorded until July 31, 2020. RESULTS: Endocrine toxicity occurred in 70 out of 251 patients (27.89%). It was mostly related to thyroid dysfunction and in 75% of cases occurred within 6 months from the beginning of therapy. A previous endocrine morbidity and female gender were predictors of endocrine toxicity. There was no association between endocrine dysfunction and patient outcome. However, when all toxicities (i.e., endocrine and non endocrine) were considered, a significant association with progression-free survival and overall survival was found. CONCLUSIONS: Thyroid alterations are frequently observed in cancer patients treated with anti PD-1 drugs, particularly in women and in the presence of a previous endocrinopathy. We suggest that regular thyroid assessment should be performed in these patients, especially in the first months of therapy. Finally, the onset of side effects, related to anti PD-1 agents, appears to be associated with a better outcome. Springer US 2021-05-25 2021 /pmc/articles/PMC8440282/ /pubmed/34036513 http://dx.doi.org/10.1007/s12020-021-02750-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Rubino, Rossella Marini, Andrea Roviello, Giandomenico Presotto, Elena Margherita Desideri, Isacco Ciardetti, Isabella Brugia, Marco Pimpinelli, Nicola Antonuzzo, Lorenzo Mini, Enrico Livi, Lorenzo Maggi, Mario Peri, Alessandro Endocrine-related adverse events in a large series of cancer patients treated with anti-PD1 therapy |
title | Endocrine-related adverse events in a large series of cancer patients treated with anti-PD1 therapy |
title_full | Endocrine-related adverse events in a large series of cancer patients treated with anti-PD1 therapy |
title_fullStr | Endocrine-related adverse events in a large series of cancer patients treated with anti-PD1 therapy |
title_full_unstemmed | Endocrine-related adverse events in a large series of cancer patients treated with anti-PD1 therapy |
title_short | Endocrine-related adverse events in a large series of cancer patients treated with anti-PD1 therapy |
title_sort | endocrine-related adverse events in a large series of cancer patients treated with anti-pd1 therapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440282/ https://www.ncbi.nlm.nih.gov/pubmed/34036513 http://dx.doi.org/10.1007/s12020-021-02750-w |
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