Cargando…

2D and 3D numerical models to evaluate trabecular bone damage

The comprehension of trabecular bone damage processes could be a crucial hint for understanding how bone damage starts and propagates. Currently, different approaches to bone damage identification could be followed. Clinical approaches start from dual X-ray absorptiometry (DXA) technique that can ev...

Descripción completa

Detalles Bibliográficos
Autores principales: Buccino, Federica, Colombo, Chiara, Duarte, Daniel Hernando Lozano, Rinaudo, Luca, Ulivieri, Fabio Massimo, Vergani, Laura Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440311/
https://www.ncbi.nlm.nih.gov/pubmed/34471983
http://dx.doi.org/10.1007/s11517-021-02422-x
_version_ 1783752684223856640
author Buccino, Federica
Colombo, Chiara
Duarte, Daniel Hernando Lozano
Rinaudo, Luca
Ulivieri, Fabio Massimo
Vergani, Laura Maria
author_facet Buccino, Federica
Colombo, Chiara
Duarte, Daniel Hernando Lozano
Rinaudo, Luca
Ulivieri, Fabio Massimo
Vergani, Laura Maria
author_sort Buccino, Federica
collection PubMed
description The comprehension of trabecular bone damage processes could be a crucial hint for understanding how bone damage starts and propagates. Currently, different approaches to bone damage identification could be followed. Clinical approaches start from dual X-ray absorptiometry (DXA) technique that can evaluate bone mineral density (BMD), an indirect indicator of fracture risk. DXA is, in fact, a two-dimensional technology, and BMD alone is not able to predict the effective risk of fractures. First attempts in overcoming this issue have been performed with finite element (FE) methods, combined with the use of three-dimensional high-resolution micro-computed tomographic images. The purpose of this work is to evaluate damage initiation and propagation in trabecular vertebral porcine samples using 2D linear-elastic FE models from DXA images and 3D linear FE models from micro-CT images. Results show that computed values of strains with 2D and 3D approaches (e.g., the minimum principal strain) are of the same order of magnitude. 2D DXA-based models still remain a powerful tool for a preliminary screening of trabecular regions that are prone to fracture, while from 3D micro-CT-based models, it is possible to reach details that permit the localization of the most strained trabecula. GRAPHICAL ABSTRACT: [Image: see text]
format Online
Article
Text
id pubmed-8440311
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-84403112021-10-01 2D and 3D numerical models to evaluate trabecular bone damage Buccino, Federica Colombo, Chiara Duarte, Daniel Hernando Lozano Rinaudo, Luca Ulivieri, Fabio Massimo Vergani, Laura Maria Med Biol Eng Comput Original Article The comprehension of trabecular bone damage processes could be a crucial hint for understanding how bone damage starts and propagates. Currently, different approaches to bone damage identification could be followed. Clinical approaches start from dual X-ray absorptiometry (DXA) technique that can evaluate bone mineral density (BMD), an indirect indicator of fracture risk. DXA is, in fact, a two-dimensional technology, and BMD alone is not able to predict the effective risk of fractures. First attempts in overcoming this issue have been performed with finite element (FE) methods, combined with the use of three-dimensional high-resolution micro-computed tomographic images. The purpose of this work is to evaluate damage initiation and propagation in trabecular vertebral porcine samples using 2D linear-elastic FE models from DXA images and 3D linear FE models from micro-CT images. Results show that computed values of strains with 2D and 3D approaches (e.g., the minimum principal strain) are of the same order of magnitude. 2D DXA-based models still remain a powerful tool for a preliminary screening of trabecular regions that are prone to fracture, while from 3D micro-CT-based models, it is possible to reach details that permit the localization of the most strained trabecula. GRAPHICAL ABSTRACT: [Image: see text] Springer Berlin Heidelberg 2021-09-01 2021 /pmc/articles/PMC8440311/ /pubmed/34471983 http://dx.doi.org/10.1007/s11517-021-02422-x Text en © The Author(s) 2021, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Buccino, Federica
Colombo, Chiara
Duarte, Daniel Hernando Lozano
Rinaudo, Luca
Ulivieri, Fabio Massimo
Vergani, Laura Maria
2D and 3D numerical models to evaluate trabecular bone damage
title 2D and 3D numerical models to evaluate trabecular bone damage
title_full 2D and 3D numerical models to evaluate trabecular bone damage
title_fullStr 2D and 3D numerical models to evaluate trabecular bone damage
title_full_unstemmed 2D and 3D numerical models to evaluate trabecular bone damage
title_short 2D and 3D numerical models to evaluate trabecular bone damage
title_sort 2d and 3d numerical models to evaluate trabecular bone damage
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440311/
https://www.ncbi.nlm.nih.gov/pubmed/34471983
http://dx.doi.org/10.1007/s11517-021-02422-x
work_keys_str_mv AT buccinofederica 2dand3dnumericalmodelstoevaluatetrabecularbonedamage
AT colombochiara 2dand3dnumericalmodelstoevaluatetrabecularbonedamage
AT duartedanielhernandolozano 2dand3dnumericalmodelstoevaluatetrabecularbonedamage
AT rinaudoluca 2dand3dnumericalmodelstoevaluatetrabecularbonedamage
AT ulivierifabiomassimo 2dand3dnumericalmodelstoevaluatetrabecularbonedamage
AT verganilauramaria 2dand3dnumericalmodelstoevaluatetrabecularbonedamage