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Evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder

Schizophrenia (SZ) and autism spectrum disorder (ASD) share considerable clinical features and intertwined historical roots. It is greatly needed to explore their similarities and differences in pathophysiologic mechanisms. We assembled a large sample size of neuroimaging data (about 600 SZ patients...

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Autores principales: Du, Yuhui, Fu, Zening, Xing, Ying, Lin, Dongdong, Pearlson, Godfrey, Kochunov, Peter, Hong, L. Elliot, Qi, Shile, Salman, Mustafa, Abrol, Anees, Calhoun, Vince D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440519/
https://www.ncbi.nlm.nih.gov/pubmed/34521980
http://dx.doi.org/10.1038/s42003-021-02592-2
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author Du, Yuhui
Fu, Zening
Xing, Ying
Lin, Dongdong
Pearlson, Godfrey
Kochunov, Peter
Hong, L. Elliot
Qi, Shile
Salman, Mustafa
Abrol, Anees
Calhoun, Vince D.
author_facet Du, Yuhui
Fu, Zening
Xing, Ying
Lin, Dongdong
Pearlson, Godfrey
Kochunov, Peter
Hong, L. Elliot
Qi, Shile
Salman, Mustafa
Abrol, Anees
Calhoun, Vince D.
author_sort Du, Yuhui
collection PubMed
description Schizophrenia (SZ) and autism spectrum disorder (ASD) share considerable clinical features and intertwined historical roots. It is greatly needed to explore their similarities and differences in pathophysiologic mechanisms. We assembled a large sample size of neuroimaging data (about 600 SZ patients, 1000 ASD patients, and 1700 healthy controls) to study the shared and unique brain abnormality of the two illnesses. We analyzed multi-scale brain functional connectivity among functional networks and brain regions, intra-network connectivity, and cerebral gray matter density and volume. Both SZ and ASD showed lower functional integration within default mode and sensorimotor domains, but increased interaction between cognitive control and default mode domains. The shared abnormalties in intra-network connectivity involved default mode, sensorimotor, and cognitive control networks. Reduced gray matter volume and density in the occipital gyrus and cerebellum were observed in both illnesses. Interestingly, ASD had overall weaker changes than SZ in the shared abnormalities. Interaction between visual and cognitive regions showed disorder-unique deficits. In summary, we provide strong neuroimaging evidence of the convergent and divergent changes in SZ and ASD that correlated with clinical features.
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spelling pubmed-84405192021-10-04 Evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder Du, Yuhui Fu, Zening Xing, Ying Lin, Dongdong Pearlson, Godfrey Kochunov, Peter Hong, L. Elliot Qi, Shile Salman, Mustafa Abrol, Anees Calhoun, Vince D. Commun Biol Article Schizophrenia (SZ) and autism spectrum disorder (ASD) share considerable clinical features and intertwined historical roots. It is greatly needed to explore their similarities and differences in pathophysiologic mechanisms. We assembled a large sample size of neuroimaging data (about 600 SZ patients, 1000 ASD patients, and 1700 healthy controls) to study the shared and unique brain abnormality of the two illnesses. We analyzed multi-scale brain functional connectivity among functional networks and brain regions, intra-network connectivity, and cerebral gray matter density and volume. Both SZ and ASD showed lower functional integration within default mode and sensorimotor domains, but increased interaction between cognitive control and default mode domains. The shared abnormalties in intra-network connectivity involved default mode, sensorimotor, and cognitive control networks. Reduced gray matter volume and density in the occipital gyrus and cerebellum were observed in both illnesses. Interestingly, ASD had overall weaker changes than SZ in the shared abnormalities. Interaction between visual and cognitive regions showed disorder-unique deficits. In summary, we provide strong neuroimaging evidence of the convergent and divergent changes in SZ and ASD that correlated with clinical features. Nature Publishing Group UK 2021-09-14 /pmc/articles/PMC8440519/ /pubmed/34521980 http://dx.doi.org/10.1038/s42003-021-02592-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Du, Yuhui
Fu, Zening
Xing, Ying
Lin, Dongdong
Pearlson, Godfrey
Kochunov, Peter
Hong, L. Elliot
Qi, Shile
Salman, Mustafa
Abrol, Anees
Calhoun, Vince D.
Evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder
title Evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder
title_full Evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder
title_fullStr Evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder
title_full_unstemmed Evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder
title_short Evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder
title_sort evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440519/
https://www.ncbi.nlm.nih.gov/pubmed/34521980
http://dx.doi.org/10.1038/s42003-021-02592-2
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