Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells

EOMES and T-BET are related T-box transcription factors that control natural killer (NK) cell development. Here we demonstrate that EOMES and T-BET regulate largely distinct gene sets during this process. EOMES is dominantly expressed in immature NK cells and drives early lineage specification by in...

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Detalles Bibliográficos
Autores principales: Zhang, Jiang, Le Gras, Stéphanie, Pouxvielh, Kevin, Faure, Fabrice, Fallone, Lucie, Kern, Nicolas, Moreews, Marion, Mathieu, Anne-Laure, Schneider, Raphaël, Marliac, Quentin, Jung, Mathieu, Berton, Aurore, Hayek, Simon, Vidalain, Pierre-Olivier, Marçais, Antoine, Dodard, Garvin, Dejean, Anne, Brossay, Laurent, Ghavi-Helm, Yad, Walzer, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440589/
https://www.ncbi.nlm.nih.gov/pubmed/34521844
http://dx.doi.org/10.1038/s41467-021-25758-2

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