Cargando…
Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state
Much hope in drug development comes from the discovery of positive allosteric modulators (PAM) that display target subtype selectivity and act by increasing agonist potency and efficacy. How such compounds can allosterically influence agonist action remains unclear. Metabotropic glutamate receptors...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440590/ https://www.ncbi.nlm.nih.gov/pubmed/34521824 http://dx.doi.org/10.1038/s41467-021-25620-5 |