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Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen
To determine longitudinal changes in choriocapillaris (CC) measures in eyes with reticular pseudodrusen (RPD) using optical coherence tomography angiography (OCTA). In this observational prospective study, 20 patients with exclusively RPD and no other alteration due to age-related macular degenerati...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440680/ https://www.ncbi.nlm.nih.gov/pubmed/34521974 http://dx.doi.org/10.1038/s41598-021-97771-w |
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author | Clemens, Christoph R. Lauermann, Jost L. Schmitz, Boris Eter, Nicole Alten, Florian |
author_facet | Clemens, Christoph R. Lauermann, Jost L. Schmitz, Boris Eter, Nicole Alten, Florian |
author_sort | Clemens, Christoph R. |
collection | PubMed |
description | To determine longitudinal changes in choriocapillaris (CC) measures in eyes with reticular pseudodrusen (RPD) using optical coherence tomography angiography (OCTA). In this observational prospective study, 20 patients with exclusively RPD and no other alteration due to age-related macular degeneration were included. Eight RPD patients were re-examined at 5-year follow-up. Multimodal imaging was performed at baseline and at 5-year follow-up. OCTA CC images were analyzed for number, size and total area of flow deficits (FD), mean signal intensity, signal intensity standard deviation and kurtosis of signal intensity distribution in the ring area between a circle of 4 mm diameter and a circle of 6 mm diameter and in the superior ring quadrant. Area affected by RPD increased from 19.36 ± 8.39 mm(2) at baseline to 37.77 ± 9.03 mm(2) at 5-year follow-up. At baseline, percent of CC FD area was greater in RPD eyes (quadrant: p < 0.001; ring: p < 0.001) compared to controls. Besides, RPD eyes revealed a lower mean intensity signal (quadrant: p < 0.001; ring: p < 0.001). Evaluation of CC parameters suggested significant group × time interaction effects for CC FD (p = 0.04) and mean intensity signal (p = 0.004), in that RPD eyes presented increased CC FD and decreased mean intensity signal at follow-up. OCTA CC decorrelation signal further decreases in RPD patients over 5 years in both RPD-affected and RPD-unaffected macular areas. |
format | Online Article Text |
id | pubmed-8440680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84406802021-09-20 Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen Clemens, Christoph R. Lauermann, Jost L. Schmitz, Boris Eter, Nicole Alten, Florian Sci Rep Article To determine longitudinal changes in choriocapillaris (CC) measures in eyes with reticular pseudodrusen (RPD) using optical coherence tomography angiography (OCTA). In this observational prospective study, 20 patients with exclusively RPD and no other alteration due to age-related macular degeneration were included. Eight RPD patients were re-examined at 5-year follow-up. Multimodal imaging was performed at baseline and at 5-year follow-up. OCTA CC images were analyzed for number, size and total area of flow deficits (FD), mean signal intensity, signal intensity standard deviation and kurtosis of signal intensity distribution in the ring area between a circle of 4 mm diameter and a circle of 6 mm diameter and in the superior ring quadrant. Area affected by RPD increased from 19.36 ± 8.39 mm(2) at baseline to 37.77 ± 9.03 mm(2) at 5-year follow-up. At baseline, percent of CC FD area was greater in RPD eyes (quadrant: p < 0.001; ring: p < 0.001) compared to controls. Besides, RPD eyes revealed a lower mean intensity signal (quadrant: p < 0.001; ring: p < 0.001). Evaluation of CC parameters suggested significant group × time interaction effects for CC FD (p = 0.04) and mean intensity signal (p = 0.004), in that RPD eyes presented increased CC FD and decreased mean intensity signal at follow-up. OCTA CC decorrelation signal further decreases in RPD patients over 5 years in both RPD-affected and RPD-unaffected macular areas. Nature Publishing Group UK 2021-09-14 /pmc/articles/PMC8440680/ /pubmed/34521974 http://dx.doi.org/10.1038/s41598-021-97771-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Clemens, Christoph R. Lauermann, Jost L. Schmitz, Boris Eter, Nicole Alten, Florian Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen |
title | Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen |
title_full | Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen |
title_fullStr | Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen |
title_full_unstemmed | Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen |
title_short | Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen |
title_sort | longitudinal choriocapillaris changes in the presence of reticular pseudodrusen |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440680/ https://www.ncbi.nlm.nih.gov/pubmed/34521974 http://dx.doi.org/10.1038/s41598-021-97771-w |
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