Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes

Lysine-selective molecular tweezers are promising drug candidates against proteinopathies, viral infection, and bacterial biofilm. Despite demonstration of their efficacy in multiple cellular and animal models, important questions regarding their mechanism of action, including cell penetrance and in...

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Detalles Bibliográficos
Autores principales: Li, Zizheng, Siddique, Ibrar, Hadrović, Inesa, Kirupakaran, Abbna, Li, Jiwen, Zhang, Ye, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440717/
https://www.ncbi.nlm.nih.gov/pubmed/34521989
http://dx.doi.org/10.1038/s42003-021-02603-2

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