Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina

Chemical investigation of an endophytic fungus Diaporthe foeniculina SCBG-15, led to the isolation of eight new cyclohexanone derivatives, foeniculins A–H (1–8) and three new phenolic acid derivatives, foeniculins I–K (9–11). Their structures were extensively established on the basis of (1)H and (13...

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Autores principales: Lu, Xiuxiang, Zhang, Yanjiang, Zhang, Wenge, Wang, Huan, Zhang, Jun, Wang, Sasa, Tan, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440800/
https://www.ncbi.nlm.nih.gov/pubmed/34540805
http://dx.doi.org/10.3389/fchem.2021.738307
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author Lu, Xiuxiang
Zhang, Yanjiang
Zhang, Wenge
Wang, Huan
Zhang, Jun
Wang, Sasa
Tan, Haibo
author_facet Lu, Xiuxiang
Zhang, Yanjiang
Zhang, Wenge
Wang, Huan
Zhang, Jun
Wang, Sasa
Tan, Haibo
author_sort Lu, Xiuxiang
collection PubMed
description Chemical investigation of an endophytic fungus Diaporthe foeniculina SCBG-15, led to the isolation of eight new cyclohexanone derivatives, foeniculins A–H (1–8) and three new phenolic acid derivatives, foeniculins I–K (9–11). Their structures were extensively established on the basis of (1)H and (13)C NMR spectra together with COSY, HSQC, HMBC, and NOESY experiments. The absolute configurations were confirmed by quantum chemical ECD calculations and single-crystal X-ray diffractions. Moreover, the in vitro cytotoxic and antibacterial activities of isolated compounds 1–11 were also evaluated.
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spelling pubmed-84408002021-09-16 Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina Lu, Xiuxiang Zhang, Yanjiang Zhang, Wenge Wang, Huan Zhang, Jun Wang, Sasa Tan, Haibo Front Chem Chemistry Chemical investigation of an endophytic fungus Diaporthe foeniculina SCBG-15, led to the isolation of eight new cyclohexanone derivatives, foeniculins A–H (1–8) and three new phenolic acid derivatives, foeniculins I–K (9–11). Their structures were extensively established on the basis of (1)H and (13)C NMR spectra together with COSY, HSQC, HMBC, and NOESY experiments. The absolute configurations were confirmed by quantum chemical ECD calculations and single-crystal X-ray diffractions. Moreover, the in vitro cytotoxic and antibacterial activities of isolated compounds 1–11 were also evaluated. Frontiers Media S.A. 2021-09-01 /pmc/articles/PMC8440800/ /pubmed/34540805 http://dx.doi.org/10.3389/fchem.2021.738307 Text en Copyright © 2021 Lu, Zhang, Zhang, Wang, Zhang, Wang and Tan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Lu, Xiuxiang
Zhang, Yanjiang
Zhang, Wenge
Wang, Huan
Zhang, Jun
Wang, Sasa
Tan, Haibo
Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina
title Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina
title_full Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina
title_fullStr Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina
title_full_unstemmed Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina
title_short Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina
title_sort cyclohexanone and phenolic acid derivatives from endophytic fungus diaporthe foeniculina
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440800/
https://www.ncbi.nlm.nih.gov/pubmed/34540805
http://dx.doi.org/10.3389/fchem.2021.738307
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