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Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins

Accurate orchestration of gene expression is critical for the process of normal hematopoiesis, and dysregulation is closely associated with leukemogenesis. Epigenetic aberration is one of the major causes contributing to acute myeloid leukemia (AML), where chromosomal rearrangements are frequently f...

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Detalles Bibliográficos
Autores principales: Zhang, Juan, Gao, Xuefeng, Yu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440836/
https://www.ncbi.nlm.nih.gov/pubmed/34540702
http://dx.doi.org/10.3389/fonc.2021.741746
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author Zhang, Juan
Gao, Xuefeng
Yu, Li
author_facet Zhang, Juan
Gao, Xuefeng
Yu, Li
author_sort Zhang, Juan
collection PubMed
description Accurate orchestration of gene expression is critical for the process of normal hematopoiesis, and dysregulation is closely associated with leukemogenesis. Epigenetic aberration is one of the major causes contributing to acute myeloid leukemia (AML), where chromosomal rearrangements are frequently found. Increasing evidences have shown the pivotal roles of histone deacetylases (HDACs) in chromatin remodeling, which are involved in stemness maintenance, cell fate determination, proliferation and differentiation, via mastering the transcriptional switch of key genes. In abnormal, these functions can be bloomed to elicit carcinogenesis. Presently, HDAC family members are appealing targets for drug exploration, many of which have been deployed to the AML treatment. As the majority of AML events are associated with chromosomal translocation resulting in oncogenic fusion proteins, it is valuable to comprehensively understand the mutual interactions between HDACs and oncogenic proteins. Therefore, we reviewed the process of leukemogenesis and roles of HDAC members acting in this progress, providing an insight for the target anchoring, investigation of hyperacetylated-agents, and how the current knowledge could be applied in AML treatment.
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spelling pubmed-84408362021-09-16 Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins Zhang, Juan Gao, Xuefeng Yu, Li Front Oncol Oncology Accurate orchestration of gene expression is critical for the process of normal hematopoiesis, and dysregulation is closely associated with leukemogenesis. Epigenetic aberration is one of the major causes contributing to acute myeloid leukemia (AML), where chromosomal rearrangements are frequently found. Increasing evidences have shown the pivotal roles of histone deacetylases (HDACs) in chromatin remodeling, which are involved in stemness maintenance, cell fate determination, proliferation and differentiation, via mastering the transcriptional switch of key genes. In abnormal, these functions can be bloomed to elicit carcinogenesis. Presently, HDAC family members are appealing targets for drug exploration, many of which have been deployed to the AML treatment. As the majority of AML events are associated with chromosomal translocation resulting in oncogenic fusion proteins, it is valuable to comprehensively understand the mutual interactions between HDACs and oncogenic proteins. Therefore, we reviewed the process of leukemogenesis and roles of HDAC members acting in this progress, providing an insight for the target anchoring, investigation of hyperacetylated-agents, and how the current knowledge could be applied in AML treatment. Frontiers Media S.A. 2021-09-01 /pmc/articles/PMC8440836/ /pubmed/34540702 http://dx.doi.org/10.3389/fonc.2021.741746 Text en Copyright © 2021 Zhang, Gao and Yu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Juan
Gao, Xuefeng
Yu, Li
Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins
title Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins
title_full Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins
title_fullStr Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins
title_full_unstemmed Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins
title_short Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins
title_sort roles of histone deacetylases in acute myeloid leukemia with fusion proteins
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440836/
https://www.ncbi.nlm.nih.gov/pubmed/34540702
http://dx.doi.org/10.3389/fonc.2021.741746
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