Cargando…
Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins
Accurate orchestration of gene expression is critical for the process of normal hematopoiesis, and dysregulation is closely associated with leukemogenesis. Epigenetic aberration is one of the major causes contributing to acute myeloid leukemia (AML), where chromosomal rearrangements are frequently f...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440836/ https://www.ncbi.nlm.nih.gov/pubmed/34540702 http://dx.doi.org/10.3389/fonc.2021.741746 |
_version_ | 1783752748703940608 |
---|---|
author | Zhang, Juan Gao, Xuefeng Yu, Li |
author_facet | Zhang, Juan Gao, Xuefeng Yu, Li |
author_sort | Zhang, Juan |
collection | PubMed |
description | Accurate orchestration of gene expression is critical for the process of normal hematopoiesis, and dysregulation is closely associated with leukemogenesis. Epigenetic aberration is one of the major causes contributing to acute myeloid leukemia (AML), where chromosomal rearrangements are frequently found. Increasing evidences have shown the pivotal roles of histone deacetylases (HDACs) in chromatin remodeling, which are involved in stemness maintenance, cell fate determination, proliferation and differentiation, via mastering the transcriptional switch of key genes. In abnormal, these functions can be bloomed to elicit carcinogenesis. Presently, HDAC family members are appealing targets for drug exploration, many of which have been deployed to the AML treatment. As the majority of AML events are associated with chromosomal translocation resulting in oncogenic fusion proteins, it is valuable to comprehensively understand the mutual interactions between HDACs and oncogenic proteins. Therefore, we reviewed the process of leukemogenesis and roles of HDAC members acting in this progress, providing an insight for the target anchoring, investigation of hyperacetylated-agents, and how the current knowledge could be applied in AML treatment. |
format | Online Article Text |
id | pubmed-8440836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84408362021-09-16 Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins Zhang, Juan Gao, Xuefeng Yu, Li Front Oncol Oncology Accurate orchestration of gene expression is critical for the process of normal hematopoiesis, and dysregulation is closely associated with leukemogenesis. Epigenetic aberration is one of the major causes contributing to acute myeloid leukemia (AML), where chromosomal rearrangements are frequently found. Increasing evidences have shown the pivotal roles of histone deacetylases (HDACs) in chromatin remodeling, which are involved in stemness maintenance, cell fate determination, proliferation and differentiation, via mastering the transcriptional switch of key genes. In abnormal, these functions can be bloomed to elicit carcinogenesis. Presently, HDAC family members are appealing targets for drug exploration, many of which have been deployed to the AML treatment. As the majority of AML events are associated with chromosomal translocation resulting in oncogenic fusion proteins, it is valuable to comprehensively understand the mutual interactions between HDACs and oncogenic proteins. Therefore, we reviewed the process of leukemogenesis and roles of HDAC members acting in this progress, providing an insight for the target anchoring, investigation of hyperacetylated-agents, and how the current knowledge could be applied in AML treatment. Frontiers Media S.A. 2021-09-01 /pmc/articles/PMC8440836/ /pubmed/34540702 http://dx.doi.org/10.3389/fonc.2021.741746 Text en Copyright © 2021 Zhang, Gao and Yu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhang, Juan Gao, Xuefeng Yu, Li Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins |
title | Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins |
title_full | Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins |
title_fullStr | Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins |
title_full_unstemmed | Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins |
title_short | Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins |
title_sort | roles of histone deacetylases in acute myeloid leukemia with fusion proteins |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440836/ https://www.ncbi.nlm.nih.gov/pubmed/34540702 http://dx.doi.org/10.3389/fonc.2021.741746 |
work_keys_str_mv | AT zhangjuan rolesofhistonedeacetylasesinacutemyeloidleukemiawithfusionproteins AT gaoxuefeng rolesofhistonedeacetylasesinacutemyeloidleukemiawithfusionproteins AT yuli rolesofhistonedeacetylasesinacutemyeloidleukemiawithfusionproteins |