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Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administrat...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440914/ https://www.ncbi.nlm.nih.gov/pubmed/34540888 http://dx.doi.org/10.3389/fmolb.2021.649395 |
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author | Sharifi-Rad, Javad Quispe, Cristina Mukazhanova, Zhazira Knut, Ewa Turgumbayeva, Aknur Kipchakbayeva, Aliya Seitimova, Gulnaz Mahomoodally, Mohamad Fawzi Lobine, Devina Koay, Aaron Wang, Jinfan Sheridan, Helen Leyva-Gómez, Gerardo Prado-Audelo, María L. Del Cortes, Hernán Rescigno, Antonio Zucca, Paolo Sytar, Oksana Imran, Muhammad Rodrigues, Célia F. Cruz-Martins, Natália Ekiert, Halina Kumar, Manoj Abdull Razis, Ahmad Faizal Sunusi, Usman Kamal, Ramla Muhammad Szopa, Agnieszka |
author_facet | Sharifi-Rad, Javad Quispe, Cristina Mukazhanova, Zhazira Knut, Ewa Turgumbayeva, Aknur Kipchakbayeva, Aliya Seitimova, Gulnaz Mahomoodally, Mohamad Fawzi Lobine, Devina Koay, Aaron Wang, Jinfan Sheridan, Helen Leyva-Gómez, Gerardo Prado-Audelo, María L. Del Cortes, Hernán Rescigno, Antonio Zucca, Paolo Sytar, Oksana Imran, Muhammad Rodrigues, Célia F. Cruz-Martins, Natália Ekiert, Halina Kumar, Manoj Abdull Razis, Ahmad Faizal Sunusi, Usman Kamal, Ramla Muhammad Szopa, Agnieszka |
author_sort | Sharifi-Rad, Javad |
collection | PubMed |
description | Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed. |
format | Online Article Text |
id | pubmed-8440914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84409142021-09-16 Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer Sharifi-Rad, Javad Quispe, Cristina Mukazhanova, Zhazira Knut, Ewa Turgumbayeva, Aknur Kipchakbayeva, Aliya Seitimova, Gulnaz Mahomoodally, Mohamad Fawzi Lobine, Devina Koay, Aaron Wang, Jinfan Sheridan, Helen Leyva-Gómez, Gerardo Prado-Audelo, María L. Del Cortes, Hernán Rescigno, Antonio Zucca, Paolo Sytar, Oksana Imran, Muhammad Rodrigues, Célia F. Cruz-Martins, Natália Ekiert, Halina Kumar, Manoj Abdull Razis, Ahmad Faizal Sunusi, Usman Kamal, Ramla Muhammad Szopa, Agnieszka Front Mol Biosci Molecular Biosciences Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed. Frontiers Media S.A. 2021-09-01 /pmc/articles/PMC8440914/ /pubmed/34540888 http://dx.doi.org/10.3389/fmolb.2021.649395 Text en Copyright © 2021 Sharifi-Rad, Quispe, Mukazhanova, Knut, Turgumbayeva, Kipchakbayeva, Seitimova, Mahomoodally, Lobine, Koay, Wang, Sheridan, Leyva-Gómez, Prado-Audelo, Cortes, Rescigno, Zucca, Sytar, Imran, Rodrigues, Cruz-Martins, Ekiert, Kumar, Abdull Razis, Sunusi, Kamal and Szopa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Sharifi-Rad, Javad Quispe, Cristina Mukazhanova, Zhazira Knut, Ewa Turgumbayeva, Aknur Kipchakbayeva, Aliya Seitimova, Gulnaz Mahomoodally, Mohamad Fawzi Lobine, Devina Koay, Aaron Wang, Jinfan Sheridan, Helen Leyva-Gómez, Gerardo Prado-Audelo, María L. Del Cortes, Hernán Rescigno, Antonio Zucca, Paolo Sytar, Oksana Imran, Muhammad Rodrigues, Célia F. Cruz-Martins, Natália Ekiert, Halina Kumar, Manoj Abdull Razis, Ahmad Faizal Sunusi, Usman Kamal, Ramla Muhammad Szopa, Agnieszka Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
title | Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
title_full | Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
title_fullStr | Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
title_full_unstemmed | Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
title_short | Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
title_sort | resveratrol-based nanoformulations as an emerging therapeutic strategy for cancer |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440914/ https://www.ncbi.nlm.nih.gov/pubmed/34540888 http://dx.doi.org/10.3389/fmolb.2021.649395 |
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