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Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administrat...

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Autores principales: Sharifi-Rad, Javad, Quispe, Cristina, Mukazhanova, Zhazira, Knut, Ewa, Turgumbayeva, Aknur, Kipchakbayeva, Aliya, Seitimova, Gulnaz, Mahomoodally, Mohamad Fawzi, Lobine, Devina, Koay, Aaron, Wang, Jinfan, Sheridan, Helen, Leyva-Gómez, Gerardo, Prado-Audelo, María L. Del, Cortes, Hernán, Rescigno, Antonio, Zucca, Paolo, Sytar, Oksana, Imran, Muhammad, Rodrigues, Célia F., Cruz-Martins, Natália, Ekiert, Halina, Kumar, Manoj, Abdull Razis, Ahmad Faizal, Sunusi, Usman, Kamal, Ramla Muhammad, Szopa, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440914/
https://www.ncbi.nlm.nih.gov/pubmed/34540888
http://dx.doi.org/10.3389/fmolb.2021.649395
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author Sharifi-Rad, Javad
Quispe, Cristina
Mukazhanova, Zhazira
Knut, Ewa
Turgumbayeva, Aknur
Kipchakbayeva, Aliya
Seitimova, Gulnaz
Mahomoodally, Mohamad Fawzi
Lobine, Devina
Koay, Aaron
Wang, Jinfan
Sheridan, Helen
Leyva-Gómez, Gerardo
Prado-Audelo, María L. Del
Cortes, Hernán
Rescigno, Antonio
Zucca, Paolo
Sytar, Oksana
Imran, Muhammad
Rodrigues, Célia F.
Cruz-Martins, Natália
Ekiert, Halina
Kumar, Manoj
Abdull Razis, Ahmad Faizal
Sunusi, Usman
Kamal, Ramla Muhammad
Szopa, Agnieszka
author_facet Sharifi-Rad, Javad
Quispe, Cristina
Mukazhanova, Zhazira
Knut, Ewa
Turgumbayeva, Aknur
Kipchakbayeva, Aliya
Seitimova, Gulnaz
Mahomoodally, Mohamad Fawzi
Lobine, Devina
Koay, Aaron
Wang, Jinfan
Sheridan, Helen
Leyva-Gómez, Gerardo
Prado-Audelo, María L. Del
Cortes, Hernán
Rescigno, Antonio
Zucca, Paolo
Sytar, Oksana
Imran, Muhammad
Rodrigues, Célia F.
Cruz-Martins, Natália
Ekiert, Halina
Kumar, Manoj
Abdull Razis, Ahmad Faizal
Sunusi, Usman
Kamal, Ramla Muhammad
Szopa, Agnieszka
author_sort Sharifi-Rad, Javad
collection PubMed
description Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.
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spelling pubmed-84409142021-09-16 Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer Sharifi-Rad, Javad Quispe, Cristina Mukazhanova, Zhazira Knut, Ewa Turgumbayeva, Aknur Kipchakbayeva, Aliya Seitimova, Gulnaz Mahomoodally, Mohamad Fawzi Lobine, Devina Koay, Aaron Wang, Jinfan Sheridan, Helen Leyva-Gómez, Gerardo Prado-Audelo, María L. Del Cortes, Hernán Rescigno, Antonio Zucca, Paolo Sytar, Oksana Imran, Muhammad Rodrigues, Célia F. Cruz-Martins, Natália Ekiert, Halina Kumar, Manoj Abdull Razis, Ahmad Faizal Sunusi, Usman Kamal, Ramla Muhammad Szopa, Agnieszka Front Mol Biosci Molecular Biosciences Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed. Frontiers Media S.A. 2021-09-01 /pmc/articles/PMC8440914/ /pubmed/34540888 http://dx.doi.org/10.3389/fmolb.2021.649395 Text en Copyright © 2021 Sharifi-Rad, Quispe, Mukazhanova, Knut, Turgumbayeva, Kipchakbayeva, Seitimova, Mahomoodally, Lobine, Koay, Wang, Sheridan, Leyva-Gómez, Prado-Audelo, Cortes, Rescigno, Zucca, Sytar, Imran, Rodrigues, Cruz-Martins, Ekiert, Kumar, Abdull Razis, Sunusi, Kamal and Szopa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Sharifi-Rad, Javad
Quispe, Cristina
Mukazhanova, Zhazira
Knut, Ewa
Turgumbayeva, Aknur
Kipchakbayeva, Aliya
Seitimova, Gulnaz
Mahomoodally, Mohamad Fawzi
Lobine, Devina
Koay, Aaron
Wang, Jinfan
Sheridan, Helen
Leyva-Gómez, Gerardo
Prado-Audelo, María L. Del
Cortes, Hernán
Rescigno, Antonio
Zucca, Paolo
Sytar, Oksana
Imran, Muhammad
Rodrigues, Célia F.
Cruz-Martins, Natália
Ekiert, Halina
Kumar, Manoj
Abdull Razis, Ahmad Faizal
Sunusi, Usman
Kamal, Ramla Muhammad
Szopa, Agnieszka
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
title Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
title_full Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
title_fullStr Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
title_full_unstemmed Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
title_short Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
title_sort resveratrol-based nanoformulations as an emerging therapeutic strategy for cancer
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440914/
https://www.ncbi.nlm.nih.gov/pubmed/34540888
http://dx.doi.org/10.3389/fmolb.2021.649395
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