Two New Diterpenoids from Biscogniauxia sp. and Their Activities

Two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, (13)C chemical shifts calculations, and E...

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Detalles Bibliográficos
Autores principales: Zhao, Huan, Liu, Yue, Zhang, Meng, Chen, Guo-dong, Hu, Dan, Guo, Liang-dong, Zhao, Zhong-xiang, Zhi, Hui, Gao, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440928/
https://www.ncbi.nlm.nih.gov/pubmed/34540810
http://dx.doi.org/10.3389/fchem.2021.749272
Descripción
Sumario:Two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, (13)C chemical shifts calculations, and ECD calculations. This is the first report of diterpenoids from Biscogniauxia sp. Furthermore, short-term memory enhancement against Alzheimer’s disease (AD), anti-inflammatory, and cytotoxic activities of 1–2 were also evaluated. The results showed that compound 1 exhibited short-term memory enhancement activity against AD.

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