Two New Diterpenoids from Biscogniauxia sp. and Their Activities

Two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, (13)C chemical shifts calculations, and E...

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Autores principales: Zhao, Huan, Liu, Yue, Zhang, Meng, Chen, Guo-dong, Hu, Dan, Guo, Liang-dong, Zhao, Zhong-xiang, Zhi, Hui, Gao, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440928/
https://www.ncbi.nlm.nih.gov/pubmed/34540810
http://dx.doi.org/10.3389/fchem.2021.749272
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author Zhao, Huan
Liu, Yue
Zhang, Meng
Chen, Guo-dong
Hu, Dan
Guo, Liang-dong
Zhao, Zhong-xiang
Zhi, Hui
Gao, Hao
author_facet Zhao, Huan
Liu, Yue
Zhang, Meng
Chen, Guo-dong
Hu, Dan
Guo, Liang-dong
Zhao, Zhong-xiang
Zhi, Hui
Gao, Hao
author_sort Zhao, Huan
collection PubMed
description Two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, (13)C chemical shifts calculations, and ECD calculations. This is the first report of diterpenoids from Biscogniauxia sp. Furthermore, short-term memory enhancement against Alzheimer’s disease (AD), anti-inflammatory, and cytotoxic activities of 1–2 were also evaluated. The results showed that compound 1 exhibited short-term memory enhancement activity against AD.
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spelling pubmed-84409282021-09-16 Two New Diterpenoids from Biscogniauxia sp. and Their Activities Zhao, Huan Liu, Yue Zhang, Meng Chen, Guo-dong Hu, Dan Guo, Liang-dong Zhao, Zhong-xiang Zhi, Hui Gao, Hao Front Chem Chemistry Two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, (13)C chemical shifts calculations, and ECD calculations. This is the first report of diterpenoids from Biscogniauxia sp. Furthermore, short-term memory enhancement against Alzheimer’s disease (AD), anti-inflammatory, and cytotoxic activities of 1–2 were also evaluated. The results showed that compound 1 exhibited short-term memory enhancement activity against AD. Frontiers Media S.A. 2021-09-01 /pmc/articles/PMC8440928/ /pubmed/34540810 http://dx.doi.org/10.3389/fchem.2021.749272 Text en Copyright © 2021 Zhao, Liu, Zhang, Chen, Hu, Guo, Zhao, Zhi and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Zhao, Huan
Liu, Yue
Zhang, Meng
Chen, Guo-dong
Hu, Dan
Guo, Liang-dong
Zhao, Zhong-xiang
Zhi, Hui
Gao, Hao
Two New Diterpenoids from Biscogniauxia sp. and Their Activities
title Two New Diterpenoids from Biscogniauxia sp. and Their Activities
title_full Two New Diterpenoids from Biscogniauxia sp. and Their Activities
title_fullStr Two New Diterpenoids from Biscogniauxia sp. and Their Activities
title_full_unstemmed Two New Diterpenoids from Biscogniauxia sp. and Their Activities
title_short Two New Diterpenoids from Biscogniauxia sp. and Their Activities
title_sort two new diterpenoids from biscogniauxia sp. and their activities
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440928/
https://www.ncbi.nlm.nih.gov/pubmed/34540810
http://dx.doi.org/10.3389/fchem.2021.749272
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