Quantitative 3D microscopy highlights altered von Willebrand factor α‐granule storage in patients with von Willebrand disease with distinct pathogenic mechanisms

BACKGROUND: Platelets play a key role in hemostasis through plug formation and secretion of their granule contents at sites of endothelial injury. Defects in von Willebrand factor (VWF), a platelet α‐granule protein, are implicated in von Willebrand disease (VWD), and may lead to defective platelet...

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Detalles Bibliográficos
Autores principales: Swinkels, Maurice, Atiq, Ferdows, Bürgisser, Petra E., Slotman, Johan A., Houtsmuller, Adriaan B., de Heus, Cilia, Klumperman, Judith, Leebeek, Frank W. G., Voorberg, Jan, Jansen, Arend Jan Gerard, Bierings, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440947/
https://www.ncbi.nlm.nih.gov/pubmed/34532631
http://dx.doi.org/10.1002/rth2.12595

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