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Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) endocytosis and ind...

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Detalles Bibliográficos
Autores principales:	Nair, Jithin D., Braksator, Ellen, Yucel, Busra P., Fletcher-Jones, Alexandra, Seager, Richard, Mellor, Jack R., Bashir, Zafar I., Wilkinson, Kevin A., Henley, Jeremy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441151/ https://www.ncbi.nlm.nih.gov/pubmed/34553130 http://dx.doi.org/10.1016/j.isci.2021.103029

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