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Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease

Progress has been made in understanding coeliac disease, a relatively frequent and underappreciated immune-mediated condition that occurs in genetically predisposed individuals. However, several gaps remain in knowledge related to diagnosis and management. The gluten-free diet, currently the only av...

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Autores principales: Pinto-Sanchez, M. Ines, Silvester, Jocelyn A., Lebwohl, Benjamin, Leffler, Daniel A., Anderson, Robert P., Therrien, Amelie, Kelly, Ciaran P., Verdu, Elena F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441249/
https://www.ncbi.nlm.nih.gov/pubmed/34526700
http://dx.doi.org/10.1038/s41575-021-00511-8
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author Pinto-Sanchez, M. Ines
Silvester, Jocelyn A.
Lebwohl, Benjamin
Leffler, Daniel A.
Anderson, Robert P.
Therrien, Amelie
Kelly, Ciaran P.
Verdu, Elena F.
author_facet Pinto-Sanchez, M. Ines
Silvester, Jocelyn A.
Lebwohl, Benjamin
Leffler, Daniel A.
Anderson, Robert P.
Therrien, Amelie
Kelly, Ciaran P.
Verdu, Elena F.
author_sort Pinto-Sanchez, M. Ines
collection PubMed
description Progress has been made in understanding coeliac disease, a relatively frequent and underappreciated immune-mediated condition that occurs in genetically predisposed individuals. However, several gaps remain in knowledge related to diagnosis and management. The gluten-free diet, currently the only available management, is not curative or universally effective (some adherent patients have ongoing duodenal injury). Unprecedented numbers of emerging therapies, including some with novel tolerogenic mechanisms, are currently being investigated in clinical trials. In March 2020, the Celiac Disease Foundation and the Society for the Study of Celiac Disease convened a consensus workshop to identify high-yield areas of research that should be prioritized. Workshop participants included leading experts in clinical practice, academia, government and pharmaceutical development, as well as representatives from patient support groups in North America. This Roadmap summarizes key advances in the field of coeliac disease and provides information on important discussions from the consensus approach to address gaps and opportunities related to the pathogenesis, diagnosis and management of coeliac disease. The morbidity of coeliac disease is often underestimated, which has led to an unmet need to improve the management of these patients. Expanded research funding is needed as coeliac disease is a potentially curable disease.
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spelling pubmed-84412492021-09-15 Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease Pinto-Sanchez, M. Ines Silvester, Jocelyn A. Lebwohl, Benjamin Leffler, Daniel A. Anderson, Robert P. Therrien, Amelie Kelly, Ciaran P. Verdu, Elena F. Nat Rev Gastroenterol Hepatol Roadmap Progress has been made in understanding coeliac disease, a relatively frequent and underappreciated immune-mediated condition that occurs in genetically predisposed individuals. However, several gaps remain in knowledge related to diagnosis and management. The gluten-free diet, currently the only available management, is not curative or universally effective (some adherent patients have ongoing duodenal injury). Unprecedented numbers of emerging therapies, including some with novel tolerogenic mechanisms, are currently being investigated in clinical trials. In March 2020, the Celiac Disease Foundation and the Society for the Study of Celiac Disease convened a consensus workshop to identify high-yield areas of research that should be prioritized. Workshop participants included leading experts in clinical practice, academia, government and pharmaceutical development, as well as representatives from patient support groups in North America. This Roadmap summarizes key advances in the field of coeliac disease and provides information on important discussions from the consensus approach to address gaps and opportunities related to the pathogenesis, diagnosis and management of coeliac disease. The morbidity of coeliac disease is often underestimated, which has led to an unmet need to improve the management of these patients. Expanded research funding is needed as coeliac disease is a potentially curable disease. Nature Publishing Group UK 2021-09-15 2021 /pmc/articles/PMC8441249/ /pubmed/34526700 http://dx.doi.org/10.1038/s41575-021-00511-8 Text en © Springer Nature Limited 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Roadmap
Pinto-Sanchez, M. Ines
Silvester, Jocelyn A.
Lebwohl, Benjamin
Leffler, Daniel A.
Anderson, Robert P.
Therrien, Amelie
Kelly, Ciaran P.
Verdu, Elena F.
Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease
title Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease
title_full Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease
title_fullStr Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease
title_full_unstemmed Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease
title_short Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease
title_sort society for the study of celiac disease position statement on gaps and opportunities in coeliac disease
topic Roadmap
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441249/
https://www.ncbi.nlm.nih.gov/pubmed/34526700
http://dx.doi.org/10.1038/s41575-021-00511-8
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