Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson‐Gilford Progeria syndrome

Hutchinson‐Gilford progeria syndrome (HGPS) is a rare accelerated aging disorder most notably characterized by cardiovascular disease and premature death from myocardial infarction or stroke. The majority of cases are caused by a de novo single nucleotide mutation in the LMNA gene that activates a c...

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Detalles Bibliográficos
Autores principales: Cabral, Wayne A., Tavarez, Urraca L., Beeram, Indeevar, Yeritsyan, Diana, Boku, Yoseph D., Eckhaus, Michael A., Nazarian, Ara, Erdos, Michael R., Collins, Francis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441492/
https://www.ncbi.nlm.nih.gov/pubmed/34453483
http://dx.doi.org/10.1111/acel.13457

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