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Therapeutic antibodies under development for SARS‐CoV‐2

The world is experiencing one of the most difficult moments in history with COVID‐19, which has rapidly developed into a worldwide pandemic with a significant health and economic burden. Efforts to fight the virus, including prevention and treatment, have never stopped. However, no specific drugs or...

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Autores principales: Ma, Zetong, Zhu, MengMei, Zhang, Shuyi, Qian, Kewen, Wang, Chuqi, Fu, Wenyan, Lei, Changhai, Hu, Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441747/
https://www.ncbi.nlm.nih.gov/pubmed/34766160
http://dx.doi.org/10.1002/VIW.20200178
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author Ma, Zetong
Zhu, MengMei
Zhang, Shuyi
Qian, Kewen
Wang, Chuqi
Fu, Wenyan
Lei, Changhai
Hu, Shi
author_facet Ma, Zetong
Zhu, MengMei
Zhang, Shuyi
Qian, Kewen
Wang, Chuqi
Fu, Wenyan
Lei, Changhai
Hu, Shi
author_sort Ma, Zetong
collection PubMed
description The world is experiencing one of the most difficult moments in history with COVID‐19, which has rapidly developed into a worldwide pandemic with a significant health and economic burden. Efforts to fight the virus, including prevention and treatment, have never stopped. However, no specific drugs or treatments have yet been found. Antibody drugs have never been absent in epidemics such as SARS, MERS, HIV, Ebola, and so on in the past two decades. At present, while research on the SARS‐CoV‐2 vaccine is in full swing, antibody drugs are also receiving widespread attention. Several antibody drugs have successfully entered clinical trials and achieved impressive therapeutic effects. Here, we summarize the therapeutic antibodies against SARS‐CoV‐2, as well as the research using ACE2 recombinant protein or ACE2‐Ig fusion protein.
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spelling pubmed-84417472021-09-15 Therapeutic antibodies under development for SARS‐CoV‐2 Ma, Zetong Zhu, MengMei Zhang, Shuyi Qian, Kewen Wang, Chuqi Fu, Wenyan Lei, Changhai Hu, Shi View (Beijing) Mini‐reviews The world is experiencing one of the most difficult moments in history with COVID‐19, which has rapidly developed into a worldwide pandemic with a significant health and economic burden. Efforts to fight the virus, including prevention and treatment, have never stopped. However, no specific drugs or treatments have yet been found. Antibody drugs have never been absent in epidemics such as SARS, MERS, HIV, Ebola, and so on in the past two decades. At present, while research on the SARS‐CoV‐2 vaccine is in full swing, antibody drugs are also receiving widespread attention. Several antibody drugs have successfully entered clinical trials and achieved impressive therapeutic effects. Here, we summarize the therapeutic antibodies against SARS‐CoV‐2, as well as the research using ACE2 recombinant protein or ACE2‐Ig fusion protein. John Wiley and Sons Inc. 2021-07-12 2022-03 /pmc/articles/PMC8441747/ /pubmed/34766160 http://dx.doi.org/10.1002/VIW.20200178 Text en © 2021 The Authors. VIEW published by Shanghai Fuji Technology Consulting Co., Ltd, authorized by Professional Community of Experimental Medicine, National Association of Health Industry and Enterprise Management (PCEM) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini‐reviews
Ma, Zetong
Zhu, MengMei
Zhang, Shuyi
Qian, Kewen
Wang, Chuqi
Fu, Wenyan
Lei, Changhai
Hu, Shi
Therapeutic antibodies under development for SARS‐CoV‐2
title Therapeutic antibodies under development for SARS‐CoV‐2
title_full Therapeutic antibodies under development for SARS‐CoV‐2
title_fullStr Therapeutic antibodies under development for SARS‐CoV‐2
title_full_unstemmed Therapeutic antibodies under development for SARS‐CoV‐2
title_short Therapeutic antibodies under development for SARS‐CoV‐2
title_sort therapeutic antibodies under development for sars‐cov‐2
topic Mini‐reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441747/
https://www.ncbi.nlm.nih.gov/pubmed/34766160
http://dx.doi.org/10.1002/VIW.20200178
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