Rab35 controls formation of luminal projections required for bile canalicular morphogenesis

Hepatocytes display a unique biaxial polarity with shared apical luminal connections between adjacent hepatocytes that merge into a network of bile canaliculi. Belicova et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103003) discovered that hepatocyte apical membranes generate Rab35-depen...

Descripción completa

Detalles Bibliográficos
Autores principales: Cozmescu, Claudiu Andrei, Gissen, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441857/
https://www.ncbi.nlm.nih.gov/pubmed/34515738
http://dx.doi.org/10.1083/jcb.202108047
_version_ 1783752919487610880
author Cozmescu, Claudiu Andrei
Gissen, Paul
author_facet Cozmescu, Claudiu Andrei
Gissen, Paul
author_sort Cozmescu, Claudiu Andrei
collection PubMed
description Hepatocytes display a unique biaxial polarity with shared apical luminal connections between adjacent hepatocytes that merge into a network of bile canaliculi. Belicova et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103003) discovered that hepatocyte apical membranes generate Rab35-dependent extensions that traverse the lumen and are essential for bile canalicular formation and maintenance.
format Online
Article
Text
id pubmed-8441857
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-84418572022-04-04 Rab35 controls formation of luminal projections required for bile canalicular morphogenesis Cozmescu, Claudiu Andrei Gissen, Paul J Cell Biol Spotlight Hepatocytes display a unique biaxial polarity with shared apical luminal connections between adjacent hepatocytes that merge into a network of bile canaliculi. Belicova et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103003) discovered that hepatocyte apical membranes generate Rab35-dependent extensions that traverse the lumen and are essential for bile canalicular formation and maintenance. Rockefeller University Press 2021-09-13 /pmc/articles/PMC8441857/ /pubmed/34515738 http://dx.doi.org/10.1083/jcb.202108047 Text en © 2021 Cozmescu and Gissen http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Cozmescu, Claudiu Andrei
Gissen, Paul
Rab35 controls formation of luminal projections required for bile canalicular morphogenesis
title Rab35 controls formation of luminal projections required for bile canalicular morphogenesis
title_full Rab35 controls formation of luminal projections required for bile canalicular morphogenesis
title_fullStr Rab35 controls formation of luminal projections required for bile canalicular morphogenesis
title_full_unstemmed Rab35 controls formation of luminal projections required for bile canalicular morphogenesis
title_short Rab35 controls formation of luminal projections required for bile canalicular morphogenesis
title_sort rab35 controls formation of luminal projections required for bile canalicular morphogenesis
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441857/
https://www.ncbi.nlm.nih.gov/pubmed/34515738
http://dx.doi.org/10.1083/jcb.202108047
work_keys_str_mv AT cozmescuclaudiuandrei rab35controlsformationofluminalprojectionsrequiredforbilecanalicularmorphogenesis
AT gissenpaul rab35controlsformationofluminalprojectionsrequiredforbilecanalicularmorphogenesis

Ejemplares similares