A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche?

Multipotent hematopoietic stem cells are maintained by the bone marrow niche, but how niche-derived membrane-bound stem cell factor (mSCF) regulates HSCs remains unclear. In this issue, Hao et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202010118) describe that mSCF, synergistically with VC...

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Detalles Bibliográficos
Autores principales: Lee, Yeojin, Ding, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441858/
https://www.ncbi.nlm.nih.gov/pubmed/34516610
http://dx.doi.org/10.1083/jcb.202108031
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author Lee, Yeojin
Ding, Lei
author_facet Lee, Yeojin
Ding, Lei
author_sort Lee, Yeojin
collection PubMed
description Multipotent hematopoietic stem cells are maintained by the bone marrow niche, but how niche-derived membrane-bound stem cell factor (mSCF) regulates HSCs remains unclear. In this issue, Hao et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202010118) describe that mSCF, synergistically with VCAM-1, induces large, polarized protrusions that serve as anchors for HSCs to their niche.
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spelling pubmed-84418582022-04-04 A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche? Lee, Yeojin Ding, Lei J Cell Biol Spotlight Multipotent hematopoietic stem cells are maintained by the bone marrow niche, but how niche-derived membrane-bound stem cell factor (mSCF) regulates HSCs remains unclear. In this issue, Hao et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202010118) describe that mSCF, synergistically with VCAM-1, induces large, polarized protrusions that serve as anchors for HSCs to their niche. Rockefeller University Press 2021-09-13 /pmc/articles/PMC8441858/ /pubmed/34516610 http://dx.doi.org/10.1083/jcb.202108031 Text en © 2021 Lee and Ding http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Lee, Yeojin
Ding, Lei
A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche?
title A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche?
title_full A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche?
title_fullStr A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche?
title_full_unstemmed A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche?
title_short A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche?
title_sort polarized anchor for hematopoietic stem cells: synapse between stem cells and their niche?
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441858/
https://www.ncbi.nlm.nih.gov/pubmed/34516610
http://dx.doi.org/10.1083/jcb.202108031
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AT dinglei polarizedanchorforhematopoieticstemcellssynapsebetweenstemcellsandtheirniche

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