Cargando…

Low mortality rates among critically ill adults with COVID‐19 at three non‐academic intensive care units in south Sweden

BACKGROUND: The COVID‐19 pandemic has put an exceptional strain on intensive care units worldwide. During the first year, the survival of patients with acute hypoxaemic respiratory failure appears to have improved. We aimed to describe the mortality rates, management characteristics and two pandemic...

Descripción completa

Detalles Bibliográficos
Autores principales: Taxbro, Knut, Granath, Andreas, Sunnergren, Ola, Seifert, Stefanie, Jakubczyk, Milena N., Persson, Magnus, Hammarskjöld, Anneli, Alkemark, Catarina, Hammarskjöld, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441887/
https://www.ncbi.nlm.nih.gov/pubmed/34386972
http://dx.doi.org/10.1111/aas.13972
_version_ 1783752920694521856
author Taxbro, Knut
Granath, Andreas
Sunnergren, Ola
Seifert, Stefanie
Jakubczyk, Milena N.
Persson, Magnus
Hammarskjöld, Anneli
Alkemark, Catarina
Hammarskjöld, Fredrik
author_facet Taxbro, Knut
Granath, Andreas
Sunnergren, Ola
Seifert, Stefanie
Jakubczyk, Milena N.
Persson, Magnus
Hammarskjöld, Anneli
Alkemark, Catarina
Hammarskjöld, Fredrik
author_sort Taxbro, Knut
collection PubMed
description BACKGROUND: The COVID‐19 pandemic has put an exceptional strain on intensive care units worldwide. During the first year, the survival of patients with acute hypoxaemic respiratory failure appears to have improved. We aimed to describe the mortality rates, management characteristics and two pandemic waves during the first year at three non‐academic rural intensive care units in Sweden. METHODS: We retrospectively analysed all cases of COVID‐19 admitted to intensive care units in Region Jönköping County during 1 year. The primary endpoint was 30‐day mortality. RESULTS: Between 14th March 2020 and 13th March 2021, 264 patients were admitted to undergo intensive care with confirmed SARS‐CoV‐2 infection. The 30‐day mortality rate after the initial intensive care admission was 12.9%, and this rate remained unchanged during both pandemic waves. However, we found several distinct differences between the two pandemic waves, including an increase in the use of high‐flow nasal oxygen but a decrease in invasive mechanical ventilation use, biochemical markers of inflammation, continuous renal replacement therapy and length of stay in the intensive care unit. CONCLUSION: Our study showed that critically ill patients with COVID‐19 in Sweden have a low 30‐day mortality rate which compares well with results published from academic centres and national cohorts throughout Scandinavia. During the second pandemic wave, the proportion of patients receiving invasive mechanical ventilation and continuous renal replacement therapy was lower than that in the first wave. This could be the result of increased knowledge and improved therapeutic options.
format Online
Article
Text
id pubmed-8441887
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-84418872021-09-15 Low mortality rates among critically ill adults with COVID‐19 at three non‐academic intensive care units in south Sweden Taxbro, Knut Granath, Andreas Sunnergren, Ola Seifert, Stefanie Jakubczyk, Milena N. Persson, Magnus Hammarskjöld, Anneli Alkemark, Catarina Hammarskjöld, Fredrik Acta Anaesthesiol Scand Intensive Care and Physiology BACKGROUND: The COVID‐19 pandemic has put an exceptional strain on intensive care units worldwide. During the first year, the survival of patients with acute hypoxaemic respiratory failure appears to have improved. We aimed to describe the mortality rates, management characteristics and two pandemic waves during the first year at three non‐academic rural intensive care units in Sweden. METHODS: We retrospectively analysed all cases of COVID‐19 admitted to intensive care units in Region Jönköping County during 1 year. The primary endpoint was 30‐day mortality. RESULTS: Between 14th March 2020 and 13th March 2021, 264 patients were admitted to undergo intensive care with confirmed SARS‐CoV‐2 infection. The 30‐day mortality rate after the initial intensive care admission was 12.9%, and this rate remained unchanged during both pandemic waves. However, we found several distinct differences between the two pandemic waves, including an increase in the use of high‐flow nasal oxygen but a decrease in invasive mechanical ventilation use, biochemical markers of inflammation, continuous renal replacement therapy and length of stay in the intensive care unit. CONCLUSION: Our study showed that critically ill patients with COVID‐19 in Sweden have a low 30‐day mortality rate which compares well with results published from academic centres and national cohorts throughout Scandinavia. During the second pandemic wave, the proportion of patients receiving invasive mechanical ventilation and continuous renal replacement therapy was lower than that in the first wave. This could be the result of increased knowledge and improved therapeutic options. John Wiley and Sons Inc. 2021-09-05 2021-11 /pmc/articles/PMC8441887/ /pubmed/34386972 http://dx.doi.org/10.1111/aas.13972 Text en © 2021 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Intensive Care and Physiology
Taxbro, Knut
Granath, Andreas
Sunnergren, Ola
Seifert, Stefanie
Jakubczyk, Milena N.
Persson, Magnus
Hammarskjöld, Anneli
Alkemark, Catarina
Hammarskjöld, Fredrik
Low mortality rates among critically ill adults with COVID‐19 at three non‐academic intensive care units in south Sweden
title Low mortality rates among critically ill adults with COVID‐19 at three non‐academic intensive care units in south Sweden
title_full Low mortality rates among critically ill adults with COVID‐19 at three non‐academic intensive care units in south Sweden
title_fullStr Low mortality rates among critically ill adults with COVID‐19 at three non‐academic intensive care units in south Sweden
title_full_unstemmed Low mortality rates among critically ill adults with COVID‐19 at three non‐academic intensive care units in south Sweden
title_short Low mortality rates among critically ill adults with COVID‐19 at three non‐academic intensive care units in south Sweden
title_sort low mortality rates among critically ill adults with covid‐19 at three non‐academic intensive care units in south sweden
topic Intensive Care and Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441887/
https://www.ncbi.nlm.nih.gov/pubmed/34386972
http://dx.doi.org/10.1111/aas.13972
work_keys_str_mv AT taxbroknut lowmortalityratesamongcriticallyilladultswithcovid19atthreenonacademicintensivecareunitsinsouthsweden
AT granathandreas lowmortalityratesamongcriticallyilladultswithcovid19atthreenonacademicintensivecareunitsinsouthsweden
AT sunnergrenola lowmortalityratesamongcriticallyilladultswithcovid19atthreenonacademicintensivecareunitsinsouthsweden
AT seifertstefanie lowmortalityratesamongcriticallyilladultswithcovid19atthreenonacademicintensivecareunitsinsouthsweden
AT jakubczykmilenan lowmortalityratesamongcriticallyilladultswithcovid19atthreenonacademicintensivecareunitsinsouthsweden
AT perssonmagnus lowmortalityratesamongcriticallyilladultswithcovid19atthreenonacademicintensivecareunitsinsouthsweden
AT hammarskjoldanneli lowmortalityratesamongcriticallyilladultswithcovid19atthreenonacademicintensivecareunitsinsouthsweden
AT alkemarkcatarina lowmortalityratesamongcriticallyilladultswithcovid19atthreenonacademicintensivecareunitsinsouthsweden
AT hammarskjoldfredrik lowmortalityratesamongcriticallyilladultswithcovid19atthreenonacademicintensivecareunitsinsouthsweden
AT lowmortalityratesamongcriticallyilladultswithcovid19atthreenonacademicintensivecareunitsinsouthsweden