Cargando…
Microglia and astrocyte responses to neuropathogenic protozoan parasites
Cerebral toxoplasmosis and cerebral malaria are two important neurological diseases caused by protozoan parasites. In this review, we discuss recent findings regarding the innate immune responses of microglia and astrocytes to Toxoplasma and Plasmodium infection. In both infections, these tissue-res...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculty Opinions Ltd
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441994/ https://www.ncbi.nlm.nih.gov/pubmed/34557873 http://dx.doi.org/10.12703/r/10-69 |
_version_ | 1783752935046381568 |
---|---|
author | Nasuhidehnavi, Azadeh Yap, George S |
author_facet | Nasuhidehnavi, Azadeh Yap, George S |
author_sort | Nasuhidehnavi, Azadeh |
collection | PubMed |
description | Cerebral toxoplasmosis and cerebral malaria are two important neurological diseases caused by protozoan parasites. In this review, we discuss recent findings regarding the innate immune responses of microglia and astrocytes to Toxoplasma and Plasmodium infection. In both infections, these tissue-resident glial cells perform a sentinel function mediated by alarmin crosstalk that licenses adaptive type 1 immunity in the central nervous system. Divergent protective or pathogenic effects of type 1 activation of these astrocytes and microglia are revealed depending on the inherent lytic potential of the protozoan parasite. |
format | Online Article Text |
id | pubmed-8441994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Faculty Opinions Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-84419942021-09-22 Microglia and astrocyte responses to neuropathogenic protozoan parasites Nasuhidehnavi, Azadeh Yap, George S Fac Rev Review Article Cerebral toxoplasmosis and cerebral malaria are two important neurological diseases caused by protozoan parasites. In this review, we discuss recent findings regarding the innate immune responses of microglia and astrocytes to Toxoplasma and Plasmodium infection. In both infections, these tissue-resident glial cells perform a sentinel function mediated by alarmin crosstalk that licenses adaptive type 1 immunity in the central nervous system. Divergent protective or pathogenic effects of type 1 activation of these astrocytes and microglia are revealed depending on the inherent lytic potential of the protozoan parasite. Faculty Opinions Ltd 2021-09-03 /pmc/articles/PMC8441994/ /pubmed/34557873 http://dx.doi.org/10.12703/r/10-69 Text en Copyright: © 2021 Yap GS et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nasuhidehnavi, Azadeh Yap, George S Microglia and astrocyte responses to neuropathogenic protozoan parasites |
title | Microglia and astrocyte responses to neuropathogenic protozoan parasites |
title_full | Microglia and astrocyte responses to neuropathogenic protozoan parasites |
title_fullStr | Microglia and astrocyte responses to neuropathogenic protozoan parasites |
title_full_unstemmed | Microglia and astrocyte responses to neuropathogenic protozoan parasites |
title_short | Microglia and astrocyte responses to neuropathogenic protozoan parasites |
title_sort | microglia and astrocyte responses to neuropathogenic protozoan parasites |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441994/ https://www.ncbi.nlm.nih.gov/pubmed/34557873 http://dx.doi.org/10.12703/r/10-69 |
work_keys_str_mv | AT nasuhidehnaviazadeh microgliaandastrocyteresponsestoneuropathogenicprotozoanparasites AT yapgeorges microgliaandastrocyteresponsestoneuropathogenicprotozoanparasites |