The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep

Daily rhythms of behavior and neurophysiology are integral to the circadian clocks of all animals. Examples of circadian clock regulation in the human brain include daily rhythms in sleep-wake, cognitive function, olfactory sensitivity, and risk for ischemic stroke, all of which overlap with symptom...

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Detalles Bibliográficos
Autores principales: Herz, Rachel S., Herzog, Erik D., Merrow, Martha, Noya, Sara B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442129/
https://www.ncbi.nlm.nih.gov/pubmed/34396817
http://dx.doi.org/10.1177/07487304211031206
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author Herz, Rachel S.
Herzog, Erik D.
Merrow, Martha
Noya, Sara B.
author_facet Herz, Rachel S.
Herzog, Erik D.
Merrow, Martha
Noya, Sara B.
author_sort Herz, Rachel S.
collection PubMed
description Daily rhythms of behavior and neurophysiology are integral to the circadian clocks of all animals. Examples of circadian clock regulation in the human brain include daily rhythms in sleep-wake, cognitive function, olfactory sensitivity, and risk for ischemic stroke, all of which overlap with symptoms displayed by many COVID-19 patients. Motivated by the relatively unexplored, yet pervasive, overlap between circadian functions and COVID-19 neurological symptoms, this perspective piece uses daily variations in the sense of smell and the timing of sleep and wakefulness as illustrative examples. We propose that time-stamping clinical data and testing may expand and refine diagnosis and treatment of COVID-19.
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spelling pubmed-84421292021-09-16 The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep Herz, Rachel S. Herzog, Erik D. Merrow, Martha Noya, Sara B. J Biol Rhythms Review Daily rhythms of behavior and neurophysiology are integral to the circadian clocks of all animals. Examples of circadian clock regulation in the human brain include daily rhythms in sleep-wake, cognitive function, olfactory sensitivity, and risk for ischemic stroke, all of which overlap with symptoms displayed by many COVID-19 patients. Motivated by the relatively unexplored, yet pervasive, overlap between circadian functions and COVID-19 neurological symptoms, this perspective piece uses daily variations in the sense of smell and the timing of sleep and wakefulness as illustrative examples. We propose that time-stamping clinical data and testing may expand and refine diagnosis and treatment of COVID-19. SAGE Publications 2021-08-15 2021-10 /pmc/articles/PMC8442129/ /pubmed/34396817 http://dx.doi.org/10.1177/07487304211031206 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Herz, Rachel S.
Herzog, Erik D.
Merrow, Martha
Noya, Sara B.
The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep
title The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep
title_full The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep
title_fullStr The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep
title_full_unstemmed The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep
title_short The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep
title_sort circadian clock, the brain, and covid-19: the cases of olfaction and the timing of sleep
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442129/
https://www.ncbi.nlm.nih.gov/pubmed/34396817
http://dx.doi.org/10.1177/07487304211031206
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