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Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain
BACKGROUND: The advent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has been associated with a significant decline in coronavirus disease 2019 (COVID-19) hospitalizations and deaths. However, little is known about the benefits experienced by different population groups an...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442297/ https://www.ncbi.nlm.nih.gov/pubmed/34536609 http://dx.doi.org/10.1016/j.ijid.2021.09.022 |
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author | Barandalla, Ignacio Alvarez, Carmen Barreiro, Pablo de Mendoza, Carmen González-Crespo, Rubén Soriano, Vicente |
author_facet | Barandalla, Ignacio Alvarez, Carmen Barreiro, Pablo de Mendoza, Carmen González-Crespo, Rubén Soriano, Vicente |
author_sort | Barandalla, Ignacio |
collection | PubMed |
description | BACKGROUND: The advent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has been associated with a significant decline in coronavirus disease 2019 (COVID-19) hospitalizations and deaths. However, little is known about the benefits experienced by different population groups and/or using distinct vaccines. METHODS: The Spanish public registry was analyzed to examine associations between weekly vaccination scale-up and the incidence of COVID-19 hospitalizations by age, sex, and vaccine modality. The study period extended from January 2020 to June 2021. RESULTS: A total of 363 960 COVID-19 hospitalizations were recorded in Spain during the study period, with three peaks in March 2020, November 2020, and January 2021. The incidence of COVID-19 hospitalizations per 100 000 population increased exponentially with age, on average 71.5% for each decade older. Overall, individuals older than 60 years of age accounted for 65% of all COVID-19 hospitalizations. The speedy vaccination rollout since the end of 2020, with prioritization of the elderly groups, resulted in a rapid fall in COVID-19 hospitalizations starting in February 2021. The benefit was already noticed 3–4 weeks after the first dose, regardless of the vaccine modality. CONCLUSIONS: COVID-19 hospitalizations increased exponentially with age in all three peaks of SARS-CoV-2 infection in Spain. Early mass vaccination of people over 60 years of age prevented a fourth wave of COVID-19 hospitalizations during the spring of 2021. |
format | Online Article Text |
id | pubmed-8442297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84422972021-09-15 Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain Barandalla, Ignacio Alvarez, Carmen Barreiro, Pablo de Mendoza, Carmen González-Crespo, Rubén Soriano, Vicente Int J Infect Dis Article BACKGROUND: The advent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has been associated with a significant decline in coronavirus disease 2019 (COVID-19) hospitalizations and deaths. However, little is known about the benefits experienced by different population groups and/or using distinct vaccines. METHODS: The Spanish public registry was analyzed to examine associations between weekly vaccination scale-up and the incidence of COVID-19 hospitalizations by age, sex, and vaccine modality. The study period extended from January 2020 to June 2021. RESULTS: A total of 363 960 COVID-19 hospitalizations were recorded in Spain during the study period, with three peaks in March 2020, November 2020, and January 2021. The incidence of COVID-19 hospitalizations per 100 000 population increased exponentially with age, on average 71.5% for each decade older. Overall, individuals older than 60 years of age accounted for 65% of all COVID-19 hospitalizations. The speedy vaccination rollout since the end of 2020, with prioritization of the elderly groups, resulted in a rapid fall in COVID-19 hospitalizations starting in February 2021. The benefit was already noticed 3–4 weeks after the first dose, regardless of the vaccine modality. CONCLUSIONS: COVID-19 hospitalizations increased exponentially with age in all three peaks of SARS-CoV-2 infection in Spain. Early mass vaccination of people over 60 years of age prevented a fourth wave of COVID-19 hospitalizations during the spring of 2021. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-11 2021-09-15 /pmc/articles/PMC8442297/ /pubmed/34536609 http://dx.doi.org/10.1016/j.ijid.2021.09.022 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Barandalla, Ignacio Alvarez, Carmen Barreiro, Pablo de Mendoza, Carmen González-Crespo, Rubén Soriano, Vicente Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain |
title | Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain |
title_full | Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain |
title_fullStr | Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain |
title_full_unstemmed | Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain |
title_short | Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain |
title_sort | impact of scaling up sars-cov-2 vaccination on covid-19 hospitalizations in spain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442297/ https://www.ncbi.nlm.nih.gov/pubmed/34536609 http://dx.doi.org/10.1016/j.ijid.2021.09.022 |
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