Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment

BACKGROUND: Human genetic association studies point to immune response and lipid metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer’s disease (AD) etiology. Accumulating evidence suggests that chronic neuroinflammation, mainly mediated by microglia and astrocytes, p...

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Detalles Bibliográficos
Autores principales: Qiu, Shulan, Palavicini, Juan Pablo, Wang, Jianing, Gonzalez, Nancy S., He, Sijia, Dustin, Elizabeth, Zou, Cheng, Ding, Lin, Bhattacharjee, Anindita, Van Skike, Candice E., Galvan, Veronica, Dupree, Jeffrey L., Han, Xianlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442347/
https://www.ncbi.nlm.nih.gov/pubmed/34526055
http://dx.doi.org/10.1186/s13024-021-00488-7

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