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Normalising comparative effectiveness trials as clinical practice
There is a lack of high-quality evidence underpinning many contemporary clinical practice guidelines embedded in the healthcare systems, leading to treatment uncertainty and practice variation in most medical disciplines. Comparative effectiveness trials (CETs) represent a diverse range of research...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442385/ https://www.ncbi.nlm.nih.gov/pubmed/34526083 http://dx.doi.org/10.1186/s13063-021-05566-1 |
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author | Briffa, Tom Symons, Tanya Zeps, Nikolajs Straiton, Nicola Tarnow-Mordi, William Odita Simes, John Harris, Ian A. Cruz, Melinda Webb, Steven A. Litton, Edward Nichol, Alistair Williams, Christopher M. |
author_facet | Briffa, Tom Symons, Tanya Zeps, Nikolajs Straiton, Nicola Tarnow-Mordi, William Odita Simes, John Harris, Ian A. Cruz, Melinda Webb, Steven A. Litton, Edward Nichol, Alistair Williams, Christopher M. |
author_sort | Briffa, Tom |
collection | PubMed |
description | There is a lack of high-quality evidence underpinning many contemporary clinical practice guidelines embedded in the healthcare systems, leading to treatment uncertainty and practice variation in most medical disciplines. Comparative effectiveness trials (CETs) represent a diverse range of research that focuses on optimising health outcomes by comparing currently approved interventions to generate high-quality evidence to inform decision makers. Yet, despite their ability to produce real-world evidence that addresses the key priorities of patients and health systems, many implementation challenges exist within the healthcare environment. This manuscript aims to highlight common barriers to conducting CETs and describes potential solutions to normalise their conduct as part of a learning healthcare system. |
format | Online Article Text |
id | pubmed-8442385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-84423852021-09-15 Normalising comparative effectiveness trials as clinical practice Briffa, Tom Symons, Tanya Zeps, Nikolajs Straiton, Nicola Tarnow-Mordi, William Odita Simes, John Harris, Ian A. Cruz, Melinda Webb, Steven A. Litton, Edward Nichol, Alistair Williams, Christopher M. Trials Commentary There is a lack of high-quality evidence underpinning many contemporary clinical practice guidelines embedded in the healthcare systems, leading to treatment uncertainty and practice variation in most medical disciplines. Comparative effectiveness trials (CETs) represent a diverse range of research that focuses on optimising health outcomes by comparing currently approved interventions to generate high-quality evidence to inform decision makers. Yet, despite their ability to produce real-world evidence that addresses the key priorities of patients and health systems, many implementation challenges exist within the healthcare environment. This manuscript aims to highlight common barriers to conducting CETs and describes potential solutions to normalise their conduct as part of a learning healthcare system. BioMed Central 2021-09-15 /pmc/articles/PMC8442385/ /pubmed/34526083 http://dx.doi.org/10.1186/s13063-021-05566-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Commentary Briffa, Tom Symons, Tanya Zeps, Nikolajs Straiton, Nicola Tarnow-Mordi, William Odita Simes, John Harris, Ian A. Cruz, Melinda Webb, Steven A. Litton, Edward Nichol, Alistair Williams, Christopher M. Normalising comparative effectiveness trials as clinical practice |
title | Normalising comparative effectiveness trials as clinical practice |
title_full | Normalising comparative effectiveness trials as clinical practice |
title_fullStr | Normalising comparative effectiveness trials as clinical practice |
title_full_unstemmed | Normalising comparative effectiveness trials as clinical practice |
title_short | Normalising comparative effectiveness trials as clinical practice |
title_sort | normalising comparative effectiveness trials as clinical practice |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442385/ https://www.ncbi.nlm.nih.gov/pubmed/34526083 http://dx.doi.org/10.1186/s13063-021-05566-1 |
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