Circular RNAs’ cap-independent translation protein and its roles in carcinomas

Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and pathological processes, but their regulatory mechanisms are not fully understood. Given the development of the RNA deep-sequencing technology and the improvement...

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Autores principales: He, Lian, Man, Changfeng, Xiang, Shouyan, Yao, Lin, Wang, Xiaoyan, Fan, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442428/
https://www.ncbi.nlm.nih.gov/pubmed/34526007
http://dx.doi.org/10.1186/s12943-021-01417-4
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author He, Lian
Man, Changfeng
Xiang, Shouyan
Yao, Lin
Wang, Xiaoyan
Fan, Yu
author_facet He, Lian
Man, Changfeng
Xiang, Shouyan
Yao, Lin
Wang, Xiaoyan
Fan, Yu
author_sort He, Lian
collection PubMed
description Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and pathological processes, but their regulatory mechanisms are not fully understood. Given the development of the RNA deep-sequencing technology and the improvement of algorithms, some CircRNAs are discovered to encode proteins through the cap-independent mechanism and participate in the important process of tumorigenesis and development. Based on an overview of CircRNAs, this paper summarizes its translation mechanism and research methods, and reviews the research progress of CircRNAs translation in the field of oncology in recent years. Moreover, this paper aims to provide new ideas for tumor diagnosis and treatment through CircRNAs translation.
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spelling pubmed-84424282021-09-15 Circular RNAs’ cap-independent translation protein and its roles in carcinomas He, Lian Man, Changfeng Xiang, Shouyan Yao, Lin Wang, Xiaoyan Fan, Yu Mol Cancer Review Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and pathological processes, but their regulatory mechanisms are not fully understood. Given the development of the RNA deep-sequencing technology and the improvement of algorithms, some CircRNAs are discovered to encode proteins through the cap-independent mechanism and participate in the important process of tumorigenesis and development. Based on an overview of CircRNAs, this paper summarizes its translation mechanism and research methods, and reviews the research progress of CircRNAs translation in the field of oncology in recent years. Moreover, this paper aims to provide new ideas for tumor diagnosis and treatment through CircRNAs translation. BioMed Central 2021-09-15 /pmc/articles/PMC8442428/ /pubmed/34526007 http://dx.doi.org/10.1186/s12943-021-01417-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
He, Lian
Man, Changfeng
Xiang, Shouyan
Yao, Lin
Wang, Xiaoyan
Fan, Yu
Circular RNAs’ cap-independent translation protein and its roles in carcinomas
title Circular RNAs’ cap-independent translation protein and its roles in carcinomas
title_full Circular RNAs’ cap-independent translation protein and its roles in carcinomas
title_fullStr Circular RNAs’ cap-independent translation protein and its roles in carcinomas
title_full_unstemmed Circular RNAs’ cap-independent translation protein and its roles in carcinomas
title_short Circular RNAs’ cap-independent translation protein and its roles in carcinomas
title_sort circular rnas’ cap-independent translation protein and its roles in carcinomas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442428/
https://www.ncbi.nlm.nih.gov/pubmed/34526007
http://dx.doi.org/10.1186/s12943-021-01417-4
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