NRXN1α(+/-) is associated with increased excitability in ASD iPSC-derived neurons

BACKGROUND: NRXN1 deletions are identified as one of major rare risk factors for autism spectrum disorder (ASD) and other neurodevelopmental disorders. ASD has 30% co-morbidity with epilepsy, and the latter is associated with excessive neuronal firing. NRXN1 encodes hundreds of presynaptic neuro-adh...

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Detalles Bibliográficos
Autores principales: Avazzadeh, Sahar, Quinlan, Leo R., Reilly, Jamie, McDonagh, Katya, Jalali, Amirhossein, Wang, Yanqin, McInerney, Veronica, Krawczyk, Janusz, Ding, Yicheng, Fitzgerald, Jacqueline, O’Sullivan, Matthew, Forman, Eva B., Lynch, Sally A., Ennis, Sean, Feerick, Niamh, Reilly, Richard, Li, Weidong, Shen, Xu, Yang, Guangming, Lu, Yin, Peeters, Hilde, Dockery, Peter, O’Brien, Timothy, Shen, Sanbing, Gallagher, Louise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442436/
https://www.ncbi.nlm.nih.gov/pubmed/34525970
http://dx.doi.org/10.1186/s12868-021-00661-0

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