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Infrequent RAS mutation is not associated with specific histological phenotype in gliomas

BACKGROUND: Mutations in driver genes such as IDH and BRAF have been identified in gliomas. Meanwhile, dysregulations in the p53, RB1, and MAPK and/or PI3K pathways are involved in the molecular pathogenesis of glioblastoma. RAS family genes activate MAPK through activation of RAF and PI3K to promot...

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Detalles Bibliográficos
Autores principales:	Makino, Yasuhide, Arakawa, Yoshiki, Yoshioka, Ema, Shofuda, Tomoko, Minamiguchi, Sachiko, Kawauchi, Takeshi, Tanji, Masahiro, Kanematsu, Daisuke, Nonaka, Masahiro, Okita, Yoshiko, Kodama, Yoshinori, Mano, Masayuki, Hirose, Takanori, Mineharu, Yohei, Miyamoto, Susumu, Kanemura, Yonehiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442437/ https://www.ncbi.nlm.nih.gov/pubmed/34525976 http://dx.doi.org/10.1186/s12885-021-08733-4

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